止喘灵注射液治疗慢性阻塞性肺疾病急性加重期临床研究  

Effect of Zhichuanling injection on acute exacerbation of chronic obstructive pulmonary disease

作　　者：张爱萍[1] 陈珏 王素梅 颜小明 崔益敏 王颖[1] 张玉玲[1] 李为春 ZHANG Aiping;CHEN Jue;WANG Sumei;YAN Xiaoming;CUI Yimin;WANG Ying;ZHANG Yuling;LI Weichun(Department of Pulmonary Diseases,Jiangyan Hospital Affiliated to Nanjing University of Chinese Medicine,Taizhou,Jiangsu 225500;Department of Oncology,Affiliated Hospital of Yangzhou University,Yangzhou,Jiangsu 225001)

机构地区：[1]南京中医药大学附属姜堰医院肺病科,江苏泰州225500 [2]扬州大学附属医院肿瘤科,江苏扬州225001

出　　处：《河北中医》2025年第3期410-413,418,共5页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的观察止喘灵注射液治疗慢性阻塞性肺疾病急性加重期的效果。方法选择2023年3月至2023年10月南京中医药大学附属姜堰医院肺病科收治的60例慢性阻塞性肺疾病急性加重期患者为研究对象,按照随机数字表法分为治疗组和对照组。对照组30例予常规基础治疗,治疗组30例在对照组基础上予止喘灵注射液,均持续治疗7 d。比较2组临床疗效、中医证候积分、肺功能指标、肝肾功能指标、不良反应发生情况。结果治疗组总有效率93.33%(28/30),对照组总有效率66.67%(20/30),治疗组总有效率高于治疗组(P<0.05),临床疗效优于对照组(P<0.05)。治疗4 d和治疗7 d时,2组中医证候积分均低于本组治疗前,治疗7 d时低于本组治疗4 d时,且治疗4 d和治疗7 d时治疗组中医证候积分低于对照组同期(P<0.05)。治疗后,2组肺功能指标呼气峰值流速(PEF)、第1 s用力呼气容积(FEV_(1))、用力肺活量(FVC)、FEV_(1)/FVC水平均较本组治疗前升高(P<0.05),且治疗组均高于对照组(P<0.05)。治疗前后,2组肝肾功能相关指标比较差异无统计学意义(P>0.05)。治疗期间,2组不良反应发生率比较差异无统计学意义(P>0.05)。结论止喘灵注射液治疗慢性阻塞性肺疾病急性加重期疗效显著,可改善患者肺功能指标,降低患者中医证候积分,且不会导致肝、肾功能指标异常和增加不良反应。Objective To explore the effect of Zhichuanling injection in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods Sixty patients with AECOPD admitted to Department of Pulmonary Diseases,Jiangyan TCM Hospital Affiliated to Nanjing University of Chinese Medicine from March 2023 to October 2023 were assigned into treatment group(30 cases,treated with Zhichuanling injection and conventional treatment)and control group(30 cases,treated with conventional treatment).After 7-day treatment,the efficacy,traditional Chinese medicine(TCM)syndrome score,lung,liver and kidney function indexes,and treatment-emergent adverse events(TEAEs)were compared between groups.Results The total effective rate in the treatment group was significantly higher than that of the control group(93.33%[28/30]vs 66.67%[20/30],P<0.05).TCM syndrome scores on days 4 and 7 in the both groups were significantly lower than those before treatment,which on day 7 were significantly lower than those on day 4,and the TCM syndrome scores on days 4 and 7 in the treatment group were significantly lower than those in the control group(P<0.05).After treatment,the levels of peak expiratory flow(PEF),forced expiratory volume in one second(FEV_(1)),forced vital capacity(FVC)and FEV_(1)/FVC in the both groups were significantly higher than those before treatment(P<0.05),especially in the treatment group(P<0.05).After treatment,the liver and kidney function indexes of the both groups were comparable to those before treatment(P>0.05).The TEAEs was comparable between groups(P>0.05).Conclusion The therapeutic effect of Zhichuanling injection in AECOPD is significant.It can improve lung function indicators,reduce TCM symptom scores,without abnormal liver and kidney function indicators or TEAEs.

关 键 词：肺疾病 慢性阻塞性 止喘灵注射液 肺功能 

分 类 号：R563.905.31[医药卫生—呼吸系统]