湿润烧伤膏治疗压疮临床疗效及对炎症因子的影响  

Efficacy of moisture exposed burn ointment on pressure ulcer and its influence on inflammatory factors

作　　者：罗萍 彭晶晶 王倩 王艳丽 刘敬 李肖红 LUO Ping;PENG Jingjing;WANG Qian;WANG Yanli;LIU Jing;LI Xiaohong(Department of Ophthalmology and Otorhinolaryngology,Shunyi Hospital,Beijing Traditional Chinese Medicine Hospital,Beijing 101300;Department of Nursing,Shunyi Hospital,Beijing Traditional Chinese Medicine Hospital,Beijing 101300)

机构地区：[1]北京中医医院顺义医院五官病区,北京101300 [2]北京中医医院顺义医院护理部,北京101300

出　　处：《河北中医》2025年第3期419-422,共4页Hebei Journal of Traditional Chinese Medicine

基　　金：北京市属医院科研培育计划项目(编号:pZ2019012);顺义区卫生健康发展科研专项项目(编号:Wsjkfzkyzx-2019-q-01)。

摘　　要：目的观察湿润烧伤膏治疗压疮的疗效及对炎症因子的影响。方法选取2023年1月至2024年1月北京中医医院顺义医院64例压疮患者,按照随机数字表法分为对照组、治疗组,各32例。对照组予常规干预,治疗组在对照组基础上加湿润烧伤膏。比较2组临床疗效,以及2组治疗前后创面面积、渗液量评分、创面组织类型变化及炎症因子C反应蛋白(CRP)、白细胞介素6(IL-6)水平。结果治疗后,2组创面面积、渗液量评分均低于治疗前(P<0.05),且治疗后治疗组创面面积、渗液量评分低于对照组(P<0.05)。治疗后,2组创面组织类型均较治疗前改善(P<0.05),且治疗组改善优于对照组(P<0.05)。治疗后,2组CRP、IL-6水平均低于治疗前(P<0.05),且治疗后治疗组CRP、IL-6水平低于对照组(P<0.05)。治疗组总有效率93.75%(30/32),对照组总有效率78.13%(25/32),治疗组总有效率高于对照组(P<0.05)。结论湿润烧伤膏能促进压疮创面愈合,抑制炎症。Objective To observe the efficacy of moisture exposed burn ointment(MEBO)on pressure ulcer(PU)and its influence on inflammatory factors.Methods Sixty-four PU patients admitted to Shunyi Hospital,Beijing Traditional Chinese Medicine Hospital from January 2023 to January 2024 were randomised 1∶1 to receive routine intervention(control group)or routine intervention+MEBO(treatment group).The wound area,amount of infiltration liquid,wound tissue type,inflammatory factors(C-reactive protein[CRP]、interleukin-6[IL-6])between groups were compared.The curative effect was assessed.Results After treament,the wound area,amount of infiltration liquid in the both groups were significantly decreased(P<0.05),which were significantly decreased in the treatment group than in the control group(P<0.05).The wound tissue types in the both groups were remarkably improved compared with those before treatment(P<0.05),the improvements in the treatment group were significantly better(P<0.05).After treament,CRP,IL-6 in the both groups were significantly decreased(P<0.05),the decrease in the treatment group was more common than the control group(P<0.05).The overall effective rate in the treatment group was significantly higher than that in the control group(93.75%[30/32]vs 78.13%[25/32],P<0.05).Conclusion MEBO can promote the wound healing in PU patients,and inhibit inflammation.

关 键 词：压力性溃疡 湿润烧伤膏 伤口愈合 白细胞介素6 C反应蛋白 

分 类 号：R632.105.31[医药卫生—外科学]