全息经络铜砭刮痧配合排石汤治疗2型糖尿病合并细状肾结石临床研究  

Effect of Quanxi collateral channels stone needle scrapping combined with Paishi Soup in treating type 2 diabetes mellitus patients with thin kidney stones

作　　者：农惠玲[1] 曾丹丹 凌桂梅[2] 柳琳琳[3] NONG Huiling;ZENG Dandan;LING Guimei;LIU Linlin(Department of Nursing,Baise People's Hospital,Baise,Guangxi 533000;Department of Traditional Chinese Medicine,Baise People's Hospital,Baise,Guangxi 533000;Guangxi University of Chinese Medicine,Nanning,Guangxi 530200)

机构地区：[1]广西壮族自治区百色市人民医院护理部,广西百色533000 [2]广西壮族自治区百色市人民医院中医科,广西百色533000 [3]广西中医药大学,广西南宁530200

出　　处：《河北中医》2025年第3期477-483,共7页Hebei Journal of Traditional Chinese Medicine

基　　金：广西壮族自治区中医药局自筹经费科研课题(编号:GZZC2019150)。

摘　　要：目的观察全息经络铜砭刮痧配合排石汤治疗2型糖尿病(T2DM)合并细状肾结石的临床疗效。方法选取2019年1月至2022年12月广西壮族自治区百色市人民医院60例T2DM合并细状肾结石患者,按照随机数字表法分为3组,各20例。治疗组予全息经络铜砭刮痧配合排石汤治疗,对照组1予排石汤治疗,对照组2予全息经络铜砭刮痧治疗,10 d为1疗程,连续治疗2个疗程。比较3组临床疗效,治疗前及治疗1、2个疗程疼痛程度评分、胃肠道症状评分、机体尿液与血液生化代谢指标(尿酸、草酸、钙、磷、钾、钠、镁)及微炎症状态指标[核苷酸结合寡聚化结构域样受体3(NALP3)、白细胞介素1β(IL-1β)及肿瘤坏死因子α(TNF-α)]水平。结果治疗组总有效率高于对照组1、对照组2(P<0.05)。治疗1、2个疗程,3组疼痛视觉模拟评分、胃肠道症状(腹痛、便秘)评分及血清NALP3、IL-1β、TNF-α水平均较治疗前下降(P<0.05),且治疗组低于对照组1、对照组2(P<0.05)。治疗1个疗程,3组机体尿液及血液生化代谢指标尿酸、草酸、钙、磷、钾、钠、镁水平较治疗前升高(均P<0.05),且治疗组高于对照组1、对照组2(均P<0.05),对照组2高于对照组1(均P<0.05);治疗2个疗程,3组机体尿液及血液生化代谢指标尿酸、草酸、钙、磷、钾、钠、镁水平均较治疗前、治疗1个疗程下降(P<0.05),且治疗组低于对照组1、对照组2(均P<0.05),对照组2低于对照组1(均P<0.05)。结论全息经络铜砭刮痧配合排石汤治疗T2DM合并细状肾结石患者,疗效确切,其机制可能与调节机体代谢,减轻微炎症状态有关。Objective To explore the mechanism of Quanxi collateral channels stone needle scrapping combined with Paishi Soup in the treatment of type 2 diabetes mellitus(T2DM)with thin kidney stones.Methods Sixty T2DM patients with thin kidney stones in Baise People's Hospital of Guangxi Zhuang Autonomous Region from January 2019 to December 2022 were randomzied 1∶1∶1 to Quanxi collateral channels stone needle scrapping combined with Paishi Soup(treatment group),Paishi Soup(control group 1)or Quanxi collateral channels stone needle scrapping(control group 2).The treatment were performed for 2 courses(10 days as a course of treatment),aiming to compare the clinical efficacy,pain score,gastrointestinal symptom score(abdominal pain,constipation),urinary and blood biochemical indices(uric acid,oxalic acid,calcium,phosphorus,potassium,sodium,magnesium),microinflammatory state indices(nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3[NALP3]and interleukin1β[IL-1β]and tumor necrosis factor-α[TNF-α])among the three groups before treatment,and after 1 and 2 courses of treatment.Results The total effective rate of the treatment group was significantly higher than that of control group 1 and control group 2(P<0.05).After 1 and 2 course of treatment,pain visual analogue score(VAS),gastrointestinal symptom score and serum levels of NALP3,IL-1βand TNF-αwere significantly decreased in three groups compared with before treatment,and which were significantly decreased in treatment group compared with control group 1 and control group 2(all P<0.05).After 1 course of treatment,urine and blood biochemical metabolic indexes in the three groups were significantly increased compared with before treatment,and the levels in the treatment group were the most highest,followed by the control group 2 and control group 1(all P<0.05).After 2 courses of treatment,the levels of urine and blood biochemical metabolism indexes in the three groups were decreased compared with before treatment and after 1 cou

关 键 词：糖尿病 2型 细状肾结石 刮痧疗法 穴位全息性 排石汤 代谢 

分 类 号：R692.405.31[医药卫生—泌尿科学] R244.4[医药卫生—外科学]