2017-2022年天津市滨海新区出生队列儿童肺炎球菌疫苗接种情况分析  

Analysis on pneumonia vaccine immunization in birth cohort of children in Binhai new district of Tianjin,2017−2022

作　　者：冯欣欣 刘凤凤[1] 郝宝云 常昭瑞[1] 李中杰 Feng Xinxin;Liu Fengfeng;Hao Baoyun;Chang Zhaorui;Li Zhongjie(Division of Infectious Disease,Chinese Center for Disease Control and Prevention/National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease,Chinese Center for Disease Control and Prevention,Beijing 102206,China;Binhai New District Center for Disease Control and Prevention,Tianjin 300450,China;School of Population Medicine and Public Health,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国疾病预防控制中心传染病管理处/传染病溯源预警与智能决策全国重点实验室,北京102206 [2]天津市滨海新区疾病预防控制中心,天津300450 [3]中国医学科学院北京协和医学院群医学及公共卫生学院,北京100730

出　　处：《疾病监测》2025年第1期138-143,共6页Disease Surveillance

摘　　要：目的分析2017—2022年天津市滨海新区出生队列儿童肺炎球菌疫苗接种情况,了解儿童肺炎球菌疫苗免疫覆盖水平及首剂13价肺炎球菌多糖结合疫苗(PCV13)接种情况。方法收集2017—2022年天津市免疫规划信息系统中出生队列儿童的肺炎球菌疫苗接种信息,计算肺炎球菌疫苗接种率及PCV13首剂接种月龄构成比,利用Mann-Kendall趋势检验分析不同出生年份儿童肺炎球菌疫苗接种率及PCV13首剂接种月龄构成比的变化趋势,利用χ^(2)检验分析不同户籍儿童的接种率差异情况。结果2017—2022年天津市滨海新区出生队列儿童131802人,PCV13≥1剂次接种率、≥3剂次接种率、基础免疫接种率分别为23.47%、18.51%、20.56%;2017—2021年出生队列儿童117567人,23价肺炎球菌多糖疫苗(PPV23)接种率为13.96%。经Mann-Kendall趋势检验,2017—2022年不同出生年份本地儿童及流动儿童PCV13≥1剂次(均Z=2.630,P<0.05)、PCV13≥3剂次(均Z=2.630,P<0.05)、PCV13基础免疫接种率(均Z=2.254,P<0.05)均呈逐年增加趋势;2017—2021年不同出生年份的本地儿童及流动儿童PPV23≥1剂次接种率呈逐年下降趋势(均Z=–2.205,P<0.05)。各年份出生本地儿童的PCV13≥1剂次、PCV13≥3剂次、PCV13基础免疫接种率高于流动儿童(P<0.05);2017、2018年出生儿童中,本地儿童PPV23≥1剂次接种率高于流动儿童,差异具有统计学意义(P<0.05)。2017—2022年出生队列儿童PCV13首剂接种月龄中位数为2(2,4)月龄;不同出生年份本地儿童及流动儿童PCV13首针接种≤2月龄的人数构成比呈逐年增加趋势(均Z=2.254,P<0.05),PCV13首针接种≥16月龄的人数构成比呈逐年下降趋势(均Z=-2.630,P<0.05)。结论2017—2022年天津市滨海新区的肺炎球菌疫苗免疫覆盖水平随年份增长呈增加趋势,但流动儿童低于本地儿童。PCV13疫苗的首剂接种月龄中位数随年份增长逐年提前,但流动儿童要晚于本地儿童。提示要关注Objective To understand the coverage level of pneumonia vaccine and the first dose of the 13-valent pneumococcal polysaccharide conjugate vaccine(PCV13)immunizations in children born in Binhai new district of Tianjin from 2017 to 2022.Methods The data about pneumonia vaccine immunization in children born in Binhai during 2017-2022 were collected from Tianjin Immunization Information System,the pneumonia vaccine immunization coverage rate was calculated and the age distribution of first dose of PCV13 vaccine immunization was analyzed,Mann-Kendall trend test was used to analyze the trend of pneumonia vaccine immunization coverage rate and the age distribution of the first dose of PCV13 vaccination in different years,and x’test was used to analyze the differences between local children and migrant children.Results A total of 131802 children were enrolled in the birth cohort from 2017 to 2022.The≥1 dose,≥3 dose and primary immunization coverage rates of PCV13 in 2017-2022 birth cohort were 23.47%,18.51%and 20.56%,respectively.A total of 117567 children were enrolled in the birth cohort from 2017 to 2021.The coverage rate of one dose 23-valent pneumococcal polysaccharide vaccine(PPV23)in 2017-2021 birth cohort was 13.96%.Mann-Kendall trend test showed that the coverage rates of≥1 dose(Z=2.630,P<0.05),≥3 doses(Z=2.630,P<0.05)and primary immunizations of PCV13(Z=2.254,P<0.05)increased with year in both local children and migrant children in 2017-2022 birth cohort.The overagerate of one dose PPV23 decreased with year in both local children and migrant children in 2017-2021 birth cohort(Z=-2.205,P<0.05).In 2017-2022 birth cohort,the result of x test showed that the coverage rates of≥1 dose PCV13,≥3 doses PCV13and primary immunizations of PCV13 were higher in local children than in migrant children(P<0.05)and in children born in2017 and 2018,the coverage rate of≥1 dose PPV23 was higher in local children than in migrant children,the difference wassignificant(P<0.05).The median age for the first dose of PCV13

关 键 词：肺炎球菌疫苗 出生队列 覆盖率 

分 类 号：R211[医药卫生—中医学] R186R183.3