基于壳聚糖双胍盐的复合薄膜制备及其性能分析  

Preparation and performance analysis of a composite film based on chitosan biguanidine hydrochloride

作　　者：何智敏 时均浩 杨雅静 杨晗宇 栾亮 张权 HE Zhimin;SHI Junhao;YANG Yajing;YANG Hanyu;LUAN Liang;ZHANG Quan(School of Materials Science&Engineering,Zhejiang Sci-Tech University,Hangzhou 310018,China;Department of Laboratory Medical Center,General Hospital of Northern Theater Command,Shenyang 110016,China)

机构地区：[1]浙江理工大学材料科学与工程学院,杭州310018 [2]北部战区总医院检验科,沈阳110016

出　　处：《浙江理工大学学报(自然科学版)》2025年第2期185-197,共13页Journal of Zhejiang Sci-Tech University(Natural Sciences)

基　　金：浙江省自然科学基金项目(LY20B020001)。

摘　　要：为了阻止食品微生物污染和延长食品保质期,以壳聚糖双胍盐(Chitosan biguanidine hydrochloride, CSG)为主体原料,将其与普鲁兰多糖(Pullulan, PLL)和聚乙烯醇(Polyvinyl alcohol, PVA)混合后经溶液浇注法制备复合薄膜。分析制备所得复合薄膜的形貌和结构,探究复合薄膜的水汽屏障性、水稳定性、力学性能、热稳定性、抗菌性能以及生物相容性等性能。结果表明:通过氢键相互作用形成的复合薄膜内部结构均匀且紧密;PLL和PVA的引入不仅增强了复合薄膜的透光率和力学性能,还能提高其水蒸气阻隔性和热稳定性;复合薄膜表现出显著的抗菌效果和良好的生物相容性,对金黄色葡萄球菌和大肠埃希菌的抑菌率可达99.90%。该复合薄膜在阻止微生物污染和延长食品保质期的包装薄膜制备中具有良好的应用前景。To prevent microbial contamination and improve food preservation,a composite film was developed by blending chitosan biguanidine hydrochloride(CSG)with pullulan(PLL)and polyvinyl alcohol(PVA)using the solution casting method.The morphology and structure of the prepared composite film were analyzed,and various properties including water vapor barrier,water stability,mechanical properties,thermal stability,antibacterial efficacy,and biocompatibility were investigated.The results showed that the composite film,formed through hydrogen bonding interactions,possessed a cohesive and dense structure.Furthermore,the incorporation of PLL and PVA not only enhanced transparency and mechanical robustness of the film,but also improved water vapor barrier and thermal stability.The composite film exhibited significant antibacterial activity and excellent biocompatibility,achieving antibacterial rates of 99.90%against Staphylococcus aureus and Escherichia coli.This composite film shows great potential for packaging applications aimed at safeguarding food products against microbial contamination and extending their shelf-life.

关 键 词：壳聚糖双胍盐 普鲁兰多糖 聚乙烯醇 包装薄膜 抗菌 

分 类 号：TB324[一般工业技术—材料科学与工程]