PRISm人群进展为慢性阻塞性肺疾病的高危因素研究进展  

Research advances in risk factors for the progression to chronic obstructive pulmonary disease in individuals with preserved ratio impaired spirometry

作　　者：季雪 张静 杨阳 Ji Xue;Zhang Jing;Yang Yang(School of Medicine,University of Electronic Science and Technology of China,Chengdu 610054,China;Department of Respiratory and Critical Care Medicine,Sichuan Academy of Medical Sciences,Sichuan Provincial People′s Hospital,Chengdu 610072,China)

机构地区：[1]电子科技大学医学院,成都610054 [2]四川省医学科学院,四川省人民医院呼吸与危重症医学科,成都610072

出　　处：《国际呼吸杂志》2025年第2期178-184,共7页International Journal of Respiration

基　　金：四川省科技厅重点研发项目(2022YFS0023)。

摘　　要：保留比值受损肺功能(PRISm)是指第1秒用力呼气容积和用力肺活量成比例损害,而一秒率仍维持在正常范围的肺功能状态。PRISm人群的临床症状负担和死亡风险明显高于正常肺功能人群,同时PRISm是一种不稳定的肺功能状态,随着时间的推移,PRISm人群可恢复至正常肺功能或维持PRISm状态,但约20%~30%的患者可能出现气道阻塞,进一步发展为慢性阻塞性肺疾病。本文总结了PRISm人群进展为慢性阻塞性肺疾病的高危因素,为PRISm人群的随访管理和未来研究方向的探索提供参考。Preserved ratio impaired spirometry(PRISm)refers to a state of lung function characterized by proportional impairments in forced expiratory volume in one second(FEV 1)and forced vital capacity(FVC),while maintaining a normal FEV 1/FVC ratio.The clinical symptom burden and mortality risk are significantly higher in the PRISm population compared to those with normal lung function.PRISm is an unstable state of lung function.Over time,PRISm patients may return to normal lung function or maintain the PRISm status.However,approximately 20%-30%of patients may develop airflow obstruction and progress to chronic obstructive pulmonary disease(COPD).This review summarized the risk factor of the PRISm population in relation to the progression toward COPD,provided potential reference points for the follow-up management of PRISm patients and guided future research directions.

关 键 词：肺疾病 慢性阻塞性 保留比值受损肺功能 肺功能 

分 类 号：R47[医药卫生—护理学]