细胞微环境在钙化性主动脉瓣疾病中的作用  

Role of cellular microenvironment in calcific aortic valve disease

作　　者：刘再强 李秋煊 王志坚[1,2] LIU Zaiqiang;LI Qiuxuan;WANG Zhijian(Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China;Beijing Anzhen Nanchong Hospital of Capital Medical University,Nanchong Central Hospital,Nanchong 637000,Sichuan,China)

机构地区：[1]首都医科大学附属北京安贞医院,北京100029 [2]首都医科大学附属北京安贞医院南充医院·南充市中心医院,四川南充637000

出　　处：《西部医学》2025年第3期313-320,共8页Medical Journal of West China

基　　金：国家自然科学基金面上项目(82370449)。

摘　　要：钙化性主动脉瓣疾病(CAVD)是心血管疾病死亡主要原因之一,其患病率和发病率逐年增加。CAVD的潜在机制复杂,其病理特征是瓣叶进行性纤维化增厚和瓣膜钙化,在病程后期出现左心室流出道梗阻,引发晕厥、黑曚等临床症状。目前除了通过手术解除主动脉瓣膜狭窄外,暂无有效的药物能够延缓CAVD进展。目前认为瓣膜间质细胞(VICs)表型转化是瓣膜钙化的细胞基础,其所处的细胞微环境改变是导致表型转化的重要因素之一。综合理解细胞微环境改变对VICs表型转化的作用,对全面理解CAVD并探究潜在治疗手段有很大帮助。本文就VICs所处的微环境如何影响CAVD的进展作一述评。Calcific aortic valve disease(CAVD)is one of the main causes of death from cardiovascular diseases,and its incidence and prevalence are increasing year by year.The underlying mechanism of CAVD is complex,and its pathological features are progressive fibrosis and thickening of the valve leaflets,as well as calcification of the valve,leading to left ventricular outflow tract obstruction in the late stages of the disease,which causes syncope,blackouts,and other clinical symptoms.Currently,there are no effective drugs to delay the progression of CAVD,and surgical intervention to relieve the valve stenosis is the only option.It is currently believed that the phenotypic conversion of valve interstitial cells is the cellular basis of valve calcification,and the change of the cellular microenvironment in which they are located is one of the important factors leading to phenotypic conversion.Understanding the role of cellular microenvironment changes in valve interstitial cell phenotypic conversion is helpful for us to gain a comprehensive understanding of CAVD and explore potential treatment options.In this review,we describe how the microenvironment of the valve interstitial cells affects the progression of CAVD.

关 键 词：钙化性主动脉瓣疾病 细胞微环境 瓣膜间质细胞 瓣膜内皮细胞 

分 类 号：R542.52[医药卫生—心血管疾病]