超极速脉搏波技术评价颈动脉弹性与甘油三酯葡萄糖指数的相关性  

Association between triglyceride glucose index and carotid stiffness for assessing quantified with real-time ultrafast pulse wave velocity

作　　者：王银萍 姜学忠[2] 何健[1] WANG Yinping;JIANG Xuezhong;HE Jian(Gulou Clinical School of Nanjing Medical University,Nanjing 210029,China;Jiangsu Provincial Government Hospital,Nanjing 210029,China)

机构地区：[1]南京医科大学鼓楼临床医学院,江苏南京210029 [2]江苏省省级机关医院,江苏南京210029

出　　处：《西部医学》2025年第3期361-365,371,共6页Medical Journal of West China

基　　金：江苏省干部保健科研项目(BJ21026)。

摘　　要：目的利用超极速脉搏波(ufPWV)技术定量评估颈动脉弹性,分析甘油三酯葡萄糖指数(TyG)与动脉弹性的相关性。方法纳入2020年8月—2022年5月于江苏省省级机关医院行ufPWV检测的388名受试者,根据TyG指数四分位数,将388例志愿者分为Q1组(TyG≤8.34)、Q2组(8.3<TyG≤8.66)、Q3组(8.66<TyG≤9.10)和Q4组(TyG>9.10),每组97例。采用ufPWV技术测量每位志愿者颈动脉内中膜厚度(cIMT)、收缩起始脉搏波波速(PWV-BS)及收缩末期脉搏波波速(PWV-ES),并详细记录心血管危险因素(体重指数、低密度脂蛋白、甘油三酯、吸烟史等),分析TyG指数与动脉弹性之间的关系。结果4组在性别、年龄、体重指数、高密度脂蛋白、甘油三酯、总胆固醇、葡萄糖、尿酸、收缩压、舒张压、白细胞、血小板、糖尿病史等比较差异有统计学意义(均P<0.05),而在低密度脂蛋白、肌酐、尿素、血红蛋白、红细胞计数、谷丙转氨酶、谷草转氨酶等比较差异无统计学意义(均P>0.05)。与年龄的相关性分析显示,PWV-ES(r=0.641,P<0.001)与年龄的相关性显著优于cIMT(r=0.401,P<0.001)及PWV-BS(r=0.185,P<0.001);PWV-ES与TyG指数四分位数的增加呈正相关;PWV-ES与年龄、收缩压、体重指数、甘油三酯、低密度脂蛋白、高密度脂蛋白、TyG指数显著相关;以Q1组为参考,TyG指数在预测颈动脉硬化风险中存在性别差异,对男性的动脉硬化风险预测价值更大,并且在动脉弹性刚开始增高时预测价值更高。结论TyG指数与PWV-ES独立相关,因此ufPWV技术及其参数指标PWV-ES有助于早期发现糖尿病患者动脉粥样硬化,从而降低糖尿病患者发生心血管疾病的风险。Objective To quantitatively evaluate carotid artery elasticity by ultrafast pulse wave(ufPWV)technique,and analyze the correlation between triglyceride glucose index(TyG)and arterial elasticity.Methods A total of 388 subjects who underwent ufPWV detection in Jiangsu Provincial Government Hospital from August 2020 to May 2022 were included.The formula of TyG index was LN[fasting triglyceride(mg/dL)×fasting blood glucose(mg/dL)/2].According to the quartile of TyG index,388 volunteers were divided into Q1,Q2,Q3 and Q4 groups.Carotid intima-media thickness(cIMT),onset of systolic pulse wave velocity(PWV-BS)and end systolic pulse wave velocity(PWV-ES)were measured by ufPWV technique.Cardiovascular risk factors(body mass index,low-density lipoprotein,triglyceride,smoking history,etc.)were recorded in detail.The relationship between TyG index and arterial elasticity was analyzed.Results There were significant differences in gender,age,body mass index,high density lipoprotein,triglyceride,total cholesterol,glucose,uric acid,systolic blood pressure,diastolic blood pressure,white blood cells,platelets,history of diabetes among the four groups(all P<0.05).There were no significant differences in low density lipoprotein,creatinine,urea,hemoglobin,red blood cell count,alanine aminotransferase and aspartate aminotransferase(all P>0.05).The correlation analysis between PWV-ES(r=0.641,P<0.001)and age was significantly better than that between cIMT(r=0.401,P<0.001)and PWV-BS(r=0.185,P<0.001).PWV-ES was positively correlated with the increase of TyG quartile.PWV-ES was significantly correlated with age,systolic blood pressure,body mass index,triglyceride,low density lipoprotein,high density lipoprotein and TyG index.Taking group Q1 as a reference,there was a gender difference in the TyG index in predicting the risk of carotid atherosclerosis,and the value of TyG index in predicting the risk of carotid atherosclerosis was greater in men.And the predictive value was higher at the beginning when arterial elasticity increased.Conclus

关 键 词：超极速脉搏波 TyG指数 颈动脉弹性 动脉粥样硬化 

分 类 号：R445.1[医药卫生—影像医学与核医学] R543.5[医药卫生—诊断学]