阿司匹林联合复合维生素对妊娠期高血压患者子痫前期的预防作用  

Preventive effect of aspirin combined with compound vitamins on preeclampsia in patients with pregnancy hypertension

作　　者：张露文 范丹丹 高曼 ZHANG Luwen;FAN Dandan;GAO Man(Yongmei Group General Hospital,Shangqiu 476600,China)

机构地区：[1]永煤集团总医院,河南商丘476600

出　　处：《临床医学研究与实践》2025年第7期90-93,共4页Clinical Research and Practice

摘　　要：目的探讨阿司匹林联合复合维生素对妊娠期高血压患者子痫前期(PE)的预防作用。方法选择2021年1月至2023年2月收治的190例妊娠期高血压患者为研究对象,以随机数字表法将其分为A组(61例)、B组(65例)、C组(64例)。在口服钙剂的基础上,三组分别加服阿司匹林肠溶片、复合维生素片及阿司匹林肠溶片+复合维生素片。比较三组的治疗效果。结果治疗后,三组的舒张压(DBP)、收缩压(SBP)及24 h尿蛋白定量(24 h Upro)水平均高于治疗前,但C组的改变量低于A组、B组,A组的改变量低于B组,差异具有统计学意义(P<0.05)。治疗后,三组的内皮素(ET)、一氧化氮(NO)、总抗氧化能力(TAC)及D-二聚体(D-D)水平高于治疗前,差异具有统计学意义(P<0.05);但C组的ET、D-D改变量低于A组、B组,NO、TAC改变量高于A组、B组(P<0.05)。C组的PE发生率显著低于A组、B组(P<0.05);C组的胎盘早剥发生率显著低于B组(P<0.05);A组与B组的PE发生率及妊娠结局比较,差异无统计学意义(P>0.05)。结论在口服钙剂基础上,阿司匹林联合复合维生素能有效预防妊娠期高血压患者PE的发生,联用效果优于单用阿司匹林或复合维生素。Objective To investigate the preventive effect of aspirin combined with compound vitamins on preeclampsia(PE)in patients with pregnancy hypertension.Methods A total of 190 patients with pregnancy hypertension admitted from January 2021 to February 2023 were selected as the research objects and divided into group A(61 cases),group B(65 cases)and group C(64 cases)by random number table method.On the basis of oral calcium,the three groups were given aspirin enteric-coated tablets,compound vitamin tablets and aspirin enteric-coated tablets+compound vitamin tablets,respectively.The therapeutic effects of the three groups were compared.Results After treatment,the diastolic blood pressure(DBP),systolic blood pressure(SBP)and 24 h urine protein quantification(24 h Upro)levels in the three groups were higher than those before treatment,but the changes in the group C were lower than those in the group A and the group B,and the changes in the group A were lower than those in the group B,the differences were statistically significant(P<0.05).After treatment,the levels of endothelin(ET),nitric oxide(NO),total antioxidative capability(TAC)and D-dimer(D-D)in the three groups were higher than those before treatment,and the differences were statistically significant(P<0.05);but the changes of ET and D-D in the group C were lower than those in the group A and the group B,and the changes of NO and TAC were higher than those in the group A and the group B(P<0.05).The incidence of PE in the group C was significantly lower than that in the group A and the group B(P<0.05);the incidence of placental abruption in the group C was significantly lower than that in the group B(P<0.05);there were no significant differences in the incidence of PE and pregnancy outcome between the group A and the group B(P>0.05).Conclusion On the basis of oral calcium,aspirin combined with compound vitamins can effectively prevent the occurrence of PE in patients with pregnancy hypertension,and the combined effect is better than aspirin or compound vitamins alo

关 键 词：子痫前期 妊娠期高血压 阿司匹林 复合维生素 妊娠结局 

分 类 号：R714.25[医药卫生—妇产科学]