阿奇霉素序贯疗法治疗小儿支原体肺炎的临床效果及对炎性因子水平的影响  

Clinical effect of azithromycin sequential therapy in the treatment of Mycoplasma pneumonia in children and its influences on inflammatory factors levels

作　　者：张彤薇 ZHANG Tongwei(Pediatric Medicine Department,Anyang District Hospital,Anyang 455000,China)

机构地区：[1]濮阳市安阳地区医院小儿内科,河南安阳455000

出　　处：《临床医学研究与实践》2025年第7期94-97,共4页Clinical Research and Practice

摘　　要：目的分析阿奇霉素序贯疗法治疗小儿支原体肺炎的临床效果及对炎性因子水平的影响。方法选择2021年1月至2023年12月我院收治的80例小儿支原体肺炎患儿为研究对象,按照随机抽样法将其分为参照组与试验组,每组40例。参照组接受常规治疗,试验组予以阿奇霉素序贯疗法。比较两组的治疗效果。结果治疗后,试验组的降钙素原、干扰素-γ、C反应蛋白、肿瘤坏死因子-α水平低于参照组,白细胞介素-10水平高于参照组(P<0.05)。治疗后,试验组的血氧饱和度(SaO_(2))、动脉血氧分压(PaO_(2))高于参照组,动脉血二氧化碳分压(PaCO_(2))低于参照组(P<0.05)。试验组的发热消退时间、咳嗽消失时间、憋喘消失时间、肺部啰音消失时间、胸片阴影消失时间及住院时间均短于参照组(P<0.05)。治疗后,试验组的第1秒用力呼气容积、呼气峰值流速及用力肺活量大于参照组(P<0.05)。试验组的治疗总有效率高于参照组(P<0.05)。结论阿奇霉素序贯疗法治疗小儿支原体肺炎的效果显著,能改善通气情况、肺功能以及炎性因子水平,促进患儿康复。Objective To analyze the clinical effect of azithromycin sequential therapy in the treatment of Mycoplasma pneumonia in children and its influences on inflammatory factors levels.Methods A total of 80 children with Mycoplasma pneumonia admitted in our hospital from January 2021 to December 2023 were selected as the research objects.According to the random sampling method,the children were divided into reference group and experimental group,with 40 cases in each group.The reference group was given routine treatment,and the experimental group was given azithromycin sequential therapy.The therapeutic effects of the two groups were compared.Results After treatment,the levels of procalcitonin,interferon-γ,C-reactive protein and tumor necrosis factor-α in the experimental group were lower than those in the reference group,and the level of interleukin-10 was higher than that in the reference group(P<0.05).After treatment,blood oxygen saturation(SaO_(2))and partial pressure of oxygen in arterial blood(PaO_(2))in the experimental group were higher than those in the reference group,and partial pressure of carbon dioxide in arterial blood(PaCO_(2))was lower than that in the reference group(P<0.05).The fever regression time,cough disappearance time,wheezing disappearance time,lung rale disappearance time,chest X-ray shadow disappearance time and hospitalization time of the experimental group were shorter than those of the reference group(P<0.05).After treatment,the forced expiratory volume in the first second,peak expiratory flow rate and forced vital capacity of the experimental group were greater than those of the reference group(P<0.05).The total effective rate of treatment in the experimental group was higher than that in the reference group(P<0.05).Conclusion Azithromycin sequential therapy has a significant effect in the treatment of Mycoplasma pneumonia in children.It can improve ventilation,lung function and inflammatory factors levels,and promote the rehabilitation of children.

关 键 词：阿奇霉素 序贯疗法 支原体肺炎 小儿 炎性因子 通气状态 肺功能 

分 类 号：R725.6[医药卫生—儿科]