骨髓间充质干细胞成骨分化中ceRNA网络调控机制的研究进展  

Research Progress of ceRNA Network Regulation Mechanism in Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells

作　　者：夏楉榴 刘仕卿 孟祥睿 王荣[1] 豆银楠 铁锋 安方玉[1,2] 颜春鲁 XIA Ruoliu;LIU Shiqing;MENG Xiangrui;WANG Rong;DOU Yinnan;TIE Feng;AN Fangyu;YAN Chunlu(Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;Key Laboratory of Molecular Medicine and Chinese Medicine Prevention and Treatment of Major Diseases in Gansu Universities,Lanzhou 730000,China;Gansu Provincial Research Center of Traditional Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学,兰州730000 [2]甘肃省高校重大疾病分子医学与中医药防治研究重点实验室,兰州730000 [3]甘肃省中医药研究中心,兰州730000

出　　处：《中国现代应用药学》2025年第3期491-499,共9页Chinese Journal of Modern Applied Pharmacy

基　　金：国家自然科学基金项目(82060872);甘肃省高校教师创新基金项目(2024A-089);甘肃省联合科研基金项目(24JRRA879);定西市科技计划项目(DX2024BY017);甘肃中医药大学科学研究与创新基金项目(2023KCZD-1)。

摘　　要：骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMSCs)是一种具有自我更新和多向分化潜能的骨组织工程来源细胞。非编码RNA如长链非编码RNA(long non-coding RNA,lncRNA)和微小RNA(microRNA,miRNA)能在转录后水平控制基因表达,在BMSCs的成骨分化过程中起重要作用。lncRNA是一类无蛋白质翻译功能的RNA,参与骨骼的增殖、凋亡以及炎症反应,而miRNA作为一种小型非编码RNA,可参与调节成骨细胞相关的骨形成与破骨细胞相关的骨重塑过程。lncRNA作为竞争性内源性RNA,可以竞争性地与miRNA结合,从而间接调控miRNA靶基因的表达,影响BMSCs的成骨分化。本文主要介绍lncRNA通过靶向不同的miRNAs来调控BMSCs成骨分化的分子机制,以期初步揭示慢性骨病的发病机制,同时为慢性骨病的药物研发提供临床参考。Bone marrow mesenchymal stem cells(BMSCs)possess the ability to self-renew and differentiate in multiple directions,making them a valuable resource in bone tissue engineering.Long non-coding RNA(lncRNA)and microRNA(miRNA)are examples of non coding RNAs that exert regulatory control over gene expression at the post transcriptional level,thereby playing a significant role in the process of osteogenic differentiation of BMSCs.LncRNA lacks protein translation function but actively contributes to bone proliferation,apoptosis,and inflammatory response.Additionally,miRNA,a small non-coding RNA,plays a crucial role in regulating bone formation through osteoblasts and bone remodeling via osteoclasts.LncRNA,functioning as competitive endogenous RNA,has the ability to competitively interact with miRNA,consequently modulating the expression of miRNA target genes,thereby exerting an influence on the osteogenic differentiation of BMSC.This review primarily presents the molecular mechanism through which lncRNA modulates the osteogenic differentiation of BMSCs by targeting various miRNAs.The objective is to elucidate the underlying pathogenesis of chronic bone diseases and offer valuable clinical insights for the development of therapeutic interventions.

关 键 词：骨髓间充质干细胞 长链非编码RNA 微小RNA 竞争性内源性RNA 成骨分化 

分 类 号：R681[医药卫生—骨科学]