孕妇肠道菌群特征及其与自然流产的关系  

Characteristics of intestinal flora in pregnant women and the correlation with spontaneous abortion

作　　者：邹建琴 黄萌[2] ZOU Jianqin;HUAN-Meng(Affiliated Fuzhou First General Hospital of Fujian Medical University,Fuzhou,Fujian 350004,China;Fujian Provincial Centerfor Disease Control and Prevention,Fuzhou,Fujian 350012,China)

机构地区：[1]福建医科大学附属福州市第一总医院,福州350004 [2]福建省疾病预防控制中心,福州350012

出　　处：《福建医药杂志》2025年第2期12-16,共5页Fujian Medical Journal

基　　金：福建医科大学启航基金项目(2019QH1203)。

摘　　要：目的本研究旨在探讨肠道微生态对自然流产的影响。方法收集20例自然流产患者和20例健康对照者的粪便样本。经过16S rRNA基因测序后,对获得的原始标签进行质量过滤以获得高质量测序标签,然后将其分类到微生物基因组中。所有有效标签被聚类为操作分类单元(OTUs),并选择代表序列进行分类信息注释,随后进行α和β多样性分析。结果在所有40个样本中,共获得4527个OTUs。两组的肠道微生物群落总数不同,健康对照组的肠道菌群多样性高于自然流产组,自然流产患者中厚壁菌门和放线菌门的丰度升高,而拟杆菌门的丰度降低。结论自然流产患者存在明显的肠道菌群紊乱,可能在流产的发生发展中起重要作用。Objective To explore the influence of intestinal microecology on spontaneous abortion.Methods The fecal samples from 20 spontaneous abortion patients and 20 healthy controls were collected.After 16S rRNA gene sequencing,the obtained raw reads underwent quality filtering to obtain the clean tags and then was classified into microbial genomes.All effective tags were clustered into operational taxonomic units(OTUs),and the representative sequence was selected for the annotation of taxonomic information,followed by alpha and beta diversity analyses.Results A total of 4527 OTUs were obtained in all 40 samples.The total community of gut microbiota in the two groups was different,and the bacterial diversity of the intestinal flora in healthy controls was higher than that in the spontaneous abortion patients.The richness of Firmicutes and Actinobacteria was elevated in the spontaneous abortion patients,and that of Bacteroidota was decreased.Conclusion There is obvious intestinal microbiota disorder in spontaneous abortion patients,which plays important roles in the development of abortion.

关 键 词：肠道微生态 炎症标志物 自然流产 妊娠并发症 

分 类 号：R457.11[医药卫生—治疗学]