N^(6)-甲基腺苷甲基化修饰在巨噬细胞极化中的研究进展  

Research progress on N ^(6)-methyladenosine methylation modification in macrophage polarization

作　　者：皮慧 赵国军 PI Hui;ZHAO Guojun(Faculty of Basic Medical Sciences,Dali University,Dali 671013,China;Affiliated Qingyuan Hospital,Guangzhou Medical University,Qingyuan People's Hospital,Qingyuan 511518,China)

机构地区：[1]大理大学基础医学院,大理671013 [2]广州医科大学附属清远医院/清远市人民医院,清远511518

出　　处：《华夏医学》2025年第1期1-8,共8页Acta Medicinae Sinica

基　　金：国家自然科学基金项目(81870337);广东省自然科学基金面上项目(2024A1515012850)。

摘　　要：巨噬细胞极化是指巨噬细胞对特定微环境刺激和信号做出反应而产生不同功能表型的过程,对组织修复和维持稳态至关重要,在机体的生理和病理活动中发挥不同的调控功能。N^(6)-甲基腺苷(m^(6)A)修饰是真核细胞中最常见和最保守的内部共转录修饰,对细胞命运的调控不可或缺,通过调节基因的表达,影响细胞发育、分化、增殖和凋亡等生物过程。近年来,m^(6)A修饰通过其特定的甲基转移酶、去甲基化酶和结合蛋白,参与巨噬细胞极化的调控过程。本文主要综述m^(6)A修饰调控巨噬细胞极化的研究进展,为理解表观遗传修饰调控巨噬细胞极化机制提供新的思路。Macrophage polarization refers to the process by which macrophages acquire different functional phenotypes in response to specific microenvironmental stimuli and signals.This process is crucial for tissue repair and maintaining homeostasis,playing distinct regulatory roles in the body's physiological and pathological activities.N 6-methyladenosine(m^(6)A)modification is the most prevalent and conserved cotranscriptional modification in eukaryotic cells,and it is indispensable for regulating cell fate.By modulating gene expression,m^(6)A affects various biological processes such as cell development,differentiation,proliferation,and apoptosis.In recent years,it has been discovered that m^(6)A modification plays a key role in regulating macrophage polarization through its specific methyltransferases,demethylases,and binding proteins.This review focuses on the research progress regarding how m^(6)A modification regulates macrophage polarization,offering new insights into the epigenetic regulation of macrophage polarization mechanisms.

关 键 词：N6-甲基腺苷 表观遗传修饰 巨噬细胞极化 免疫调节 

分 类 号：R392[医药卫生—免疫学]