血清ATF6、CTRP1与冠心病冠脉狭窄程度及预后的关联  

Correlation between serum ATF6,CTRP1 and the degree and prognosis of coronary artery stenosis in coronary heart disease

作　　者：田星晨 王勇[1] 冯雪洋 TIAN Xingchen;WANG Yong;FENG Xueyang(Department of Coronary Heart Disease/Pacemaker,the First People's Hospital of Shangqiu,Shangqiu 476000,China)

机构地区：[1]商丘市第一人民医院冠心病心脏起搏器科,商丘476000

出　　处：《华夏医学》2025年第1期82-87,共6页Acta Medicinae Sinica

基　　金：河南省医学科技攻关项目(LHGJ20190302)。

摘　　要：目的分析血清激活转录因子6(ATF6)、补体C1q/肿瘤坏死因子相关蛋白1(CTRP1)与冠心病冠脉狭窄程度及预后情况的关联。方法选取105例冠心病患者,依据冠脉狭窄程度不同,将患者分为轻度组、中度组、重度组,检验血清ATF6、CTRP1与冠脉微循环参数的相关性以及对冠心病不良预后的预测效能。结果重度组CFR、FFR均低于中度组、轻度组,IMR、ATF6、CTRP1均高于中度组、轻度组,差异有统计学意义(P<0.05);ATF6与冠脉血流储备(CFR)、心肌血流储备分数(FFR)负相关,与微循环阻力指数(IMR)正相关(P<0.05);血清CTRP1与CFR、FFR负相关,与IMR正相关(P<0.05);105例冠心病的不良预后发生率为23.81%(25/105);预后不良组的ATF6、CTRP1均高于预后良好组(P<0.05);血清ATF6对冠心病不良预后的预测灵敏度、特异度分别为81.51%、79.74%,CTRP1对冠心病不良预后的预测灵敏度、特异度分别为80.36%、78.22%(AUC=0.862、0.860)。结论动态监测ATF6、CTRP1能实现对患者不良预后的早期预测。Objective To analyze the correlation between serum activating transcription factor 6(ATF6),complement C1q/tumor necrosis factor-related protein 1(CTRP1),and the degree and prognosis of coronary artery stenosis in coronary heart disease.Methods 105 patients with coronary heart disease were divided into the mild,moderate,and severe groups,and the correlation between serum ATF6,CTRP1,and coronary microcirculation parameters was examined,along with their predictive power for the poor prognosis of coronary heart disease.Results The CFR and FFR of patients in the severe group were lower than those in the moderate and mild groups,while the IMR,ATF6,and CTRP1 levels were higher than those in the moderate and mild groups,showing a statistically significant difference(P<0.05).ATF6 is negatively correlated with coronary flow reserve(CFR)and fractional myocardial flow reserve(FFR),and positively correlated with the microcirculatory resistance index(IMR)(P<0.05).Serum CTRP1 is negatively correlated with CFR and FFR,and positively correlated with the IMR(P<0.05).The incidence of poor prognosis among the 105 cases of coronary heart disease was 23.81[FGS]%[FGN](25/105).The ATF6 and CTRP1 levels in the poor prognosis group were higher than those in the good prognosis group(P<0.05).The sensitivity and specificity of serum ATF6 in predicting adverse prognosis of coronary heart disease were 81.51[FGS]%[FGN]and 79.74[FGS]%[FGN],respectively.The sensitivity and specificity of CTRP1 in predicting adverse prognosis of coronary heart disease were 80.36[FGS]%[FGN]and 78.22[FGS]%[FGN],respectively(AUC=0.862,0.860).Conclusion Dynamic monitoring of ATF6 and CTRP1 can achieve early prediction of poor prognosis in patients.

关 键 词：冠心病 冠脉狭窄程度 激活转录因子6 补体C1q/肿瘤坏死因子相关蛋白1 

分 类 号：R541.4[医药卫生—心血管疾病]