miR-92b,miR-320a与非小细胞肺癌术后生存情况的关联研究  

Association between miR-92b,miR-320a and postoperative survival in the patients with non-small cell lung cancer

作　　者：赵云萍 庞乐乐 ZHAO Yunping;PANG Lele(Department of Cardiothoracic Surgery,the Second People's Hospital of Pingdingshan City,Pingdingshan 467000,China;Department of Oncology,Nanyang Central Hospital,Nanyang 473000,China)

机构地区：[1]平顶山市第二人民医院胸心外科,平顶山467000 [2]南阳市中心医院肿瘤科,南阳473000

出　　处：《华夏医学》2025年第1期88-94,共7页Acta Medicinae Sinica

基　　金：河南省医学科技攻关项目(LHGJ202001125)。

摘　　要：目的分析微小RNA-92b(miR-92b)、微小RNA-320a(miR-320a)与非小细胞肺癌(NSCLC)术后生存情况的关联。方法回顾性分析95例中晚期NSCLC患者的一般资料,分为生存组65例、死亡组30例,归纳影响中晚期NSCLC预后的危险因素,检验miR-92b、miR-320a与NSCLC患者生存周期的相关性。结果死亡组的合并吸烟史占比、下肺叶占比、肺腺癌占比、TNM分期为Ⅳ期占比、肿瘤低分化占比、合并淋巴结转移占比、术前未实施新辅助化疗占比及miR-92b水平均高于生存组,miR-320a水平低于生存组,差异具有统计学意义(P<0.05);原发肿瘤局部淋巴结远处转移(TNM)分期为Ⅳ期、肿瘤低分化、合并淋巴结转移、术前未实施新辅助化疗、miR-92b≥1、miR-320a<1为影响NSCLC患者预后的危险因素。95例NSCLC患者中35例合并肿瘤细胞发生上皮-间质转化(EMT)。EMT组的miR-92b水平高于非EMT组,miR-320a水平低于非EMT组,无进展生存期(PFS)、总生存期(OS)均短于非EMT组(P<0.05);血清miR-19b与NSCLC患者的PFS、OS均呈负相关,miR-320a与NSCLC患者的PFS、OS均呈正相关(P<0.05)。结论miR-19b高表达、miR-320a低表达为影响NSCLC患者预后的危险因素。Objective To analyze the association between microRNA-92b(miR-92b),microRNA-320a(miR-320a)and postoperative survival in the patients with non-small cell lung cancer(NSCLC).Methods The general and clinical data of 95 patients with advanced NSCLC were retrospectively analysed.The patients were classified as the survival group(65 cases)and the death group(30 cases).The risk factors affecting the prognosis of advanced NSCLC was summarized,and the correlation between miR-92b,miR-320a and the survival cycle of NSCLC patients was analysed.Results The proportion of deaths combined with a history of smoking,the proportion of lower lung lobes,the proportion of lung adenocarcinoma,the proportion of TNM stage IV,the proportion of poorly differentiated tumors,the proportion of patients with lymph node metastasis,the proportion of patients who did not receive neoadjuvant chemotherapy before surgery,and the level of miR-92b in the death group were higher than those in the survival group,while miR-320a in the death group was lower than that in the survival group,showing a statistically significant difference(P<0.05).Tumer node metastasis(TNM)staging of stage IV,tumor low differentiation,concurrent lymph node metastasis,lack of preoperative neoadjuvant chemotherapy,miR-92b≥1,and miR-320a<1 were risk factors that affect the prognosis of NSCLC patients.Among 95 NSCLC patients,35 cases were complicated with epithelial-mesenchymal transition(EMT).The miR-92b level in the EMT group was higher than that in the non EMT group,while miR-320a,progression free survival(PFS),and overall survival(OS)were all lower than those in the non EMT group(P<0.05).Serum miR-19b is negatively correlated with PFS and OS in NSCLC patients,while miR-320a is positively correlated with PFS and OS in NSCLC patients(P<0.05).Conclusion High expression of miR-19b and low expression of miR-320a are risk factors that affect the prognosis of NSCLC patients.

关 键 词：非小细胞肺癌 微小RNA-92b 微小RNA-320a 上皮-间质转化 生存情况 

分 类 号：R723[医药卫生—儿科]