复方甘草酸苷辅助治疗急性胰腺炎的效果观察  

Observation of curative effect on compound glycyrrhizin as adjuvant therapy for the acute pancreatitis

作　　者：葛静静 李雪梅[1] GE Jingjing;LI Xuemei(Department of Pharmacy,the First People's Hospital of Shangqiu,Shangqiu 476000,China)

机构地区：[1]商丘市第一人民医院药学部,商丘476000

出　　处：《华夏医学》2025年第1期107-112,共6页Acta Medicinae Sinica

基　　金：河南省医学科技攻关项目(LHGJ2021012020)。

摘　　要：目的观察复方甘草酸苷辅助治疗急性胰腺炎(AP)对患者肝功能康复情况的影响。方法选取100例AP患者,应用电脑随机分组法分为常规组和辅助组,每组50例。常规组实施常规治疗,辅助组采用复方甘草酸苷辅助常规治疗,比较两组患者的炎症指标,氧化应激指标,肝功能指标及不良预后发生情况。结果在不同治疗方案下,辅助组的C-反应蛋白(CRP)、血清淀粉酶(AMY)、二胺氧化酶(DAO)、血清脂肪酶(LSP)水平均低于常规组,差异具有统计学意义(P<0.05);辅助组的超氧化物歧化酶(SOD)、还原型谷胱甘肽(GSH)水平均高于常规组,丙二醛(MDA)、一氧化氮(NO)水平均低于常规组(P<0.05);辅助组的谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)、总胆红素(TBiL)水平均低于常规组(P<0.05);辅助组的不良预后发生率为4.00%,低于常规组的22.00%(P<0.05)。结论复方甘草酸苷辅助治疗AP,能减轻患者炎症反应及氧化应激损伤,对改善患者肝功能并降低不良预后发生风险均有积极意义。Objective To observe the effect of compound glycyrrhizin adjuvant therapy on the liver function recovery in the patients with the acute pancreatitis(AP).Methods 100 patients with the AP were selected and were randomly divide into the conventional group and the assistant group using computer random grouping method,with 50 patients in each group.The patients in the conventional group were received conventional treatment,while the patients in the assistant group were received compound glycyrrhizin adjuvant therapy to the conventional treatment.The inflammatory indicators,oxidative stress indicators,liver function indicators,and incidence of adverse prognosis were compared between two groups patients.Results The levels of serum C-reactive protein(CRP),amylase(AMY),diamine oxidase(DAO),and lipase(LSP)in the assistant group were lower than those in the conventional group(P<0.05).The superoxide dismutase(SOD)and reduced glutathione(GSH)levels in the assistant group were higher than those in the conventional group,while,alondialdehyde(MDA),nitric oxide(NO)levels were lower than those in the conventional group(P<0.05).The alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),total bilirubin(TBiL)levels in the assistant group were lower than those in the conventional group(P<0.05).The incidence of poor prognosis in the assistant group was 4.00[FGS]%[FGN](2/50)lower than 22.00[FGS]%[FGN]in the conventional group(11/50),and the difference was statistically significant(P<0.05).Conclusion Compound glycyrrhizin adjuvant therapy alleviates the inflammation and oxidative stress damage in the patients with AP,and has a positive effect on improving the liver function and reducing the risk of adverse prognosis.

关 键 词：急性胰腺炎 复方甘草酸苷 炎症反应 氧化应激损伤 肝功能损伤 

分 类 号：R657.5[医药卫生—外科学]