血清sFlt-1、TRAF6与子痫前期病情进展及不良妊娠结局的关联研究  

Association between serum sFlt-1,TRAF6 and the progression of preeclampsia and adverse pregnancy outcomes

作　　者：何战强 董艳郦 周琳娜 HE Zhanqiang;DONG Yanli;ZHOU Linna(Obstetrics and Gynecology,the First People's Hospital of Zhumadian,Zhumadian 463800,China;Department of Obstetrics and Gynecology,Henan University of Science and Technology First Affiliated Hospital,Luoyang 471000,China)

机构地区：[1]驻马店市第一人民医院妇产科,驻马店463800 [2]河南科技大学第一附属医院产科,洛阳471000

出　　处：《华夏医学》2025年第1期131-137,共7页Acta Medicinae Sinica

基　　金：河南省医学科技攻关项目(LHGJ2021002173)。

摘　　要：目的观察血清可溶性血管内皮生长因子受体-1(sFlt-1)、肿瘤坏死因子受体相关因子6(TRAF6)与子痫前期患者病情进展及不良妊娠结局的关联。方法选取128例子痫前期患者的病例资料,分别列为预后不良组(38例)和预后良好组(90例),归纳子痫前期患者发生不良妊娠结局的危险因素。验证血清sFlt-1、TRAF6对子痫前期患者不良妊娠结局发生风险的预测价值。结果TRAF6与SBP、DBP、UTP、PI、RI、S/D正相关,差异具有统计学意义(P<0.05);年龄、BMI指数、合并GDM、SBP、DBP、UTP、PI、RI、S/D、sFlt-1、TRAF6为子痫前期患者发生不良妊娠结局的危险因素。血清sFlt-1、TRAF6对子痫前期不良妊娠结局的预测灵敏度、特异度均较高(AUC=0.863、0.861)。结论动态监测sFlt-1、TRAF6能实现对患者不良妊娠结局发生风险的早期预测。Objective To observe the association between serum soluble vascular endothelial growth factor receptor-1(sFlt-1),tumor necrosis factor receptor associated factor 6(TRAF6)and disease progression and adverse pregnancy outcomes in patients with preeclampsia.Methods 128 patients with preeclampsia were selected as the poor prognosis group(38 cases)and good prognosis group(90 cases),and summarized the risk factors for adverse pregnancy outcomes in preeclampsia patients.Verify the predictive value of serum sFlt-1 and TRAF6 for the risk of adverse pregnancy outcomes in preeclampsia patients.Results TRAF 6 was positively associated with SBP,DBP,UTP,PI,RI,S/D,with a statistically significant difference(P<0.05).Age,BMI index,combined GDM,SBP,DBP,UTP,PI,RI,S/D,sFlt-1,and TRAF 6 were risk factors for adverse pregnancy outcomes in preeclamptic patients.Serum sFlt-1 and TRAF 6 had high sensitivity and specificity for predicting adverse pregnancy outcome in preeclampsia(AUC=0.863,0.861).Conclusion Dynamic monitoring of sFlt-1 and TRAF6 can achieve early prediction of the risk of adverse pregnancy outcomes in patients.

关 键 词：子痫前期 病情进展 不良妊娠结局 可溶性血管内皮生长因子受体-1 肿瘤坏死因子受体相关因子6 

分 类 号：R71[医药卫生—妇产科学]