安坤止血汤联合复方炔诺酮片治疗围绝经期功血的效果  

Effects of Ankun Zhixue Decoction combined with compound Norethisterone tablets in the treatment of perimenopausal dysfunctional uterine bleeding

作　　者：王宁 马媛媛 李光荣[1] WANG Ning;MA Yuanyuan;LI Guangrong(Department of Obstetrics and Gynecology,Anyang Traditional Chinese Medicine Hospital,Anyang 455000,China)

机构地区：[1]安阳市中医院妇产科,安阳455000

出　　处：《华夏医学》2025年第1期152-157,共6页Acta Medicinae Sinica

基　　金：全国名老中医药专家传承工作室建设项目国中医药人教函(2022[75]号);安阳市科技发展计划课题(2022C01SF101)。

摘　　要：目的探究安坤止血汤联合复方炔诺酮片治疗围绝经期功能失调性子宫出血(功血)的效果。方法选取采用安坤止血汤联合复方炔诺酮片治疗的患者48例设为观察组,选取采用复方炔诺酮片治疗的患者48例设为对照组,共96例。比较两组临床疗效、中医证候积分、性激素水平、血流动力学水平及子宫内膜厚度、不良反应发生情况。结果治疗后,观察组临床总有效率为95.83%,高于对照组的81.25%,差异具有统计学意义(P<0.05);观察组的月经紊乱、腰膝酸软、肢冷畏寒、头晕耳鸣等中医证候积分均低于对照组(P<0.05);观察组的卵泡生成素(FSH)、黄体生成素(LH)、雌激素(E2)等性激素水平均低于对照组(P<0.05);观察组的子宫内膜厚度、阻力指数水平低于对照组,子宫动脉血流量、流速、搏动指数水平高于对照组(均P<0.05)。结论安坤止血汤联合复方炔诺酮片治疗围绝经期功血效果较佳,可改善血流动力学水平,降低性激素水平及子宫内膜厚度,缓解临床症状。Objective To explore the effect of Ankun Zhixue Decoction combined with compound Norethisterone tablets in the treatment of perimenopausal dysfunctional uterine bleeding(functional blood).Methods 48 patients treated with Ankun Zhixue Decoction combined with compound Norethisterone tablets were selected as the observation group,and 48 patients were treated with compound Norethisterone tablets were selected as the control group.There were 96 cases in total.The clinical efficacy,TCM syndrome score,sex hormone level,hemodynamic level,endometrial thickness,and adverse reactions were compared between the two groups.Results After treatment,the total clinical effective rate of the observation group was 95.83[FGS]%[FGN],which was higher than 81.25[FGS]%[FGN]of the control group,and the difference was statistically significant(P<0.05).The scores of TCM syndromes such as menstrual disorders,soreness and weakness of the waist and knees,cold limbs,dizziness and tinnitus in the observation group were lower than those in the control group(P<0.05).The levels of follicle-stimulating hormone(FSH),luteinizing hormone(LH),and estrogen(E 2)in the observation group were lower than those in the control group(P<0.05).The endometrial thickness and resistance index levels in the observation group were lower than those in the control group,while the uterine artery blood flow,flow velocity,and pulsatility index levels were higher than those in the control group(P<0.05).Conclusion Ankun Zhixue Decoction combined with compound Norethisterone tablets has better therapeutic effect on perimenopausal dysfunctional uterine bleeding,which can improve the level of hemodynamics,reduce the level of sex hormones and the thickness of the endometrium,and alleviate clinical symptoms.

关 键 词：安坤止血汤 复方炔诺酮片 功能失调性子宫出血 

分 类 号：R711.52[医药卫生—妇产科学]