活血散联合利伐沙班在髋关节置换术患者中的应用  

Application of Huoxue San combined with rivaroxaban in patients undergoing hip joint replacement surgery

作　　者：刘森 陆锋 莫永良 莫小汕 魏书亭 张禹 陀宇 LIU Sen;LU Feng;MO Yongliang;MO Xiaoshan;WEI Shuting;ZHANG Yu;TUO Yu(Department of Traditional Chinese Medicine Orthopedics,Guidong People's Hospital,Wuzhou 543001,China)

机构地区：[1]广西壮族自治区桂东人民医院中医骨伤科,梧州543001

出　　处：《华夏医学》2025年第1期158-163,共6页Acta Medicinae Sinica

基　　金：广西壮族自治区中医药管理局自筹经费科研课题(GXZYZ20210213)。

摘　　要：目的分析自拟方活血散配合利伐沙班在髋关节置换术患者中的应用效果。方法选取接受髋关节置换术的100例患者作为研究对象,按照随机数字表法分为观察组和对照组,每组50例。对照组采用口服利伐沙班等常规术后治疗,观察组在对照组的基础上予以口服活血散,分析比较两组的疼痛程度、凝血功能、血栓发生率及不良反应发生率。结果在术后24 h、48 h和72 h,观察组VAS评分均低于对照组,差异有统计学意义(P<0.05);与对照组比较,术后第7天和第14天,观察组凝血酶时间(TT)和D-二聚体浓度显著降低,术后第14天纤维蛋白原(FIB)水平也显著降低(P<0.05);而在术后第14天,观察组的C-反应蛋白(CRP)水平显著高于对照组,但血栓发生率则显著低于对照组(P<0.05);两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论活血散联合利伐沙班能够有效预防下肢深静脉血栓的形成,并且具有较高的安全性。Objective To analyze the application effect of self-made formula Huoxue San combined with rivaroxaban in patients undergoing hip replacement surgery.Methods 100 patients who underwent hip replacement surgery were selected as the research subjects and were randomly divided into the observation group and control group according to a random number table,with 50 patients in each group.The control group were received routine postoperative treatment such as oral rivaroxaban,while the observation group were received oral administration of Huoxue San in addition to the control group's treatment.The degree of pain,coagulation function,incidence of thrombosis,and incidence of adverse reactions were analyzed and compared between the two groups.Results At 24,48,and 72 h after surgery,the VAS scores of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05).Compared with the control group,the observation group showed a significant decrease in thrombin time(TT)and D-dimer concentration on the 7th and 14th d after surgery,and a significant decrease in fibrinogen(FIB)levels on the 14th d after surgery(P<0.05).On the 14th d after surgery,the level of C-reactive protein(CRP)in the observation group was significantly higher than that in the control group,but the incidence of thrombosis was significantly lower(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of Huoxue San and rivaroxaban can effectively prevent the formation of deep vein thrombosis in the lower limbs and has a high safety profile.

关 键 词：髋关节置换术 活血散 利伐沙班 临床疗效 

分 类 号：R687.3[医药卫生—骨科学]