早期益生菌辅助间歇蓝光照射治疗新生儿高胆红素血症的应用  

Application of probiotics assisted intermittent blue light irradiation in the early treatment of neonatal hyperbilirubinemia

作　　者：岳红星 阚翼 刘智慧 YUE Hongxing;KAN Yi;LIU Zhihui(Department of NICU,the First People's Hospital of Nanyang,Nanyang 473000,China)

机构地区：[1]南阳市第一人民医院NICU,南阳473000

出　　处：《华夏医学》2025年第1期164-169,共6页Acta Medicinae Sinica

基　　金：河南省医学科技攻关项目(LHGJ2021012601)。

摘　　要：目的观察早期应用益生菌辅助间歇蓝光照射治疗新生儿高胆红素血症(NHB)的应用效果。方法选取112例NHB患儿,随机分为蓝光组和辅助组,每组56例。蓝光组采用间歇蓝光照射治疗,辅助组早期应用益生菌辅助间歇蓝光照射治疗,比较两组患儿的胆红素水平即总胆红素(TBil)、直接胆红素(DBil)、间接胆红素(IBil),免疫指标(T淋巴细胞亚群CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)),电解质水平(血钾、血钠、血钙、血氯)及不良反应发生情况(皮疹过敏、电解质紊乱、腹泻、恶心呕吐)。结果在不同治疗方案下,辅助组的TBil、DBil、IBil均低于蓝光组,差异具有统计学意义(P<0.05);辅助组的CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均高于蓝光组,CD8^(+)低于蓝光组(P<0.05);辅助组的血钾、血钠、血钙、血氯以及不良反应发生率与蓝光组对比均无统计学差异(P>0.05)。结论早期应用益生菌辅助间歇蓝光照射能在不明显影响NHB患儿电解质水平同时,积极改善NHB患儿的胆红素水平及免疫功能,且联合应用益生菌未明显增加不良反应发生风险。Objective To observe the application effect of probiotics assisted intermittent blue light irradiation in the early treatment of neonatal hyperbilirubinemia(NHB).Methods 112 children with NHB were randomly divided into a blue light group and an auxiliary group,with 56 cases in each group.The blue light group were received intermittent blue light irradiation treatment,while the auxiliary group were received probiotic assisted intermittent blue light irradiation treatment in the early stage.The bilirubin levels including total bilirubin(TBil),direct bilirubin(DBil),indirect bilirubin(IBil),and immune indicators(Tlymphocyte subset CD3^(+)CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)),Electrolyte levels(blood potassium,blood sodium,blood calcium,blood chloride)and occurrence of adverse reactions(rash allergy,electrolyte imbalance,diarrhea,nausea and vomiting).Results Under different treatment plans,the TBil,DBil,and IBil levels in the auxiliary group were lower than those in the blue light group(P<0.05).The CD3^(+),CD4^(+),CD4^(+)/CD8^(+)levels in the auxiliary group were higher than those in the blue light group,while CD8^(+)levels were lower than those in the blue light group(P<0.05).There was no statistically significant difference in the incidence of blood potassium,blood sodium,blood calcium,blood chloride,and adverse reactions between the auxiliary group and the blue light group(P>0.05).Conclusion Early application of probiotics assisted intermittent blue light irradiation can actively improve the bilirubin levels and immune function of NHB children without significantly affecting their electrolyte levels,and the combined use of probiotics does not significantly increase the risk of adverse reactions.

关 键 词：新生儿高胆红素血症 益生菌 间歇蓝光照射 血清胆红素 免疫功能 

分 类 号：R722[医药卫生—儿科]