血清视黄醇水平与成人高血压风险的关联:基于NHANES数据的横断面研究  

Association Between Serum Retinol Levels and Hypertension Risk in Adults:A Cross-sectional Study Based on NHANES Data

作　　者：张雷明 刘姿 司亶 杨海涛 范宪伟 严丽洁 刘静静 李雪洁 胡娟 吴金涛 ZHANG Leiming;LIU Zi;SI Dan;YANG Haitao;FAN Xianwei;YAN Lijie;LIU Jingjing;LI Xuejie;HU Juan;WU Jintao(Department of Arrhythmia,Fuwai Central China Cardiovascular Hospital,Heart Centre of Henan Provincial People’s Hospital,Zhengzhou 450000,China;Department of Respiratory Medicine,Fuwai Central China Cardiovascular Hospital,Heart Centre of Henan Provincial People’s Hospital,Zhengzhou 450000,China;Department of Respiratory Medicine,Henan Provincial People’s Hospital,People’s Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]阜外华中心血管病医院,河南省人民医院心脏中心心律失常一病区,河南郑州450000 [2]阜外华中心血管病医院,河南省人民医院心脏中心呼吸内科,河南郑州450000 [3]河南省人民医院呼吸内科,郑州大学人民医院,河南郑州450000

出　　处：《河南医学研究》2025年第5期815-819,共5页Henan Medical Research

基　　金：河南省档案科技项目计划(2021-X-13)。

摘　　要：目的高血压是心血管疾病的主要风险因素,而视黄醇是维持人体正常功能所必需的营养素。本研究旨在基于美国国家健康与营养检查调查(NHANES)数据,分析成年人群中血清视黄醇与高血压风险的关联。方法采用横断面研究方法纳入14246名参与者。根据血清视黄醇浓度的四分位数将参与者分组,比较各组的特征,通过单因素及多因素逻辑回归模型,评估血清视黄醇水平与高血压的关联。结果参与者的年龄为(47.34±20.31)岁,51.21%为男性。随着血清视黄醇水平的升高,高血压的患病率逐渐增加,从第一四分位组(Q1:25.97%)到第二四分位组(Q2:32.21%)、第三四分位组(Q3:39.55%)和第四四分位组(Q4:52.16%)呈现显著上升趋势。多因素逻辑回归分析结果显示,在完全调整模型中,与血清视黄醇最低四分位组相比,血清视黄醇最高四分位组的高血压风险显著增加(OR=1.97,95%CI:1.73~2.25,P<0.05)。结论血清视黄醇浓度与高血压的发生风险呈正相关性。Objective Hypertension is a major risk factor for cardiovascular diseases,while retinol is an essential nutrient required for maintaining normal body functions.This study aims to analyze the association between serum retinol levels and hypertension risk among adults,based on data from the national health and nutrition examination survey(NHANES).Methods A total of 14246 participants were included in this cross-sectional study.Participants were grouped according to the quartiles of serum retinol levels,and their characteristics were compared across groups.Univariate and multivariate logistic regression models were used to assess the association between serum retinol levels and hypertension.Results The age of the participants was(47.34±20.31)years,and 51.21%were male.As serum retinol levels increased,the prevalence of hypertension gradually increased,showing a significant upward trend from the first quartile(Q1:25.97%)to the second quartile(Q2:32.21%),third quartile(Q3:39.55%),and fourth quartile(Q4:52.16%).Multivariate logistic regression analysis revealed that,in the fully adjusted model,compared to the lowest quartile of serum retinol,the highest quartile was associated with a significantly increased risk of hypertension(OR=1.97,95%CI:1.73-2.25,P<0.05).Conclusion Serum retinol concentration is positively correlated with the risk of hypertension.

关 键 词：高血压 健康与营养检查调查 视黄醇 关系 

分 类 号：R544.1[医药卫生—心血管疾病]