盐酸纳布啡复合环泊酚或丙泊酚用于冠心病患者无痛胃肠镜检查的效果对比  

Comparative of the Effects of Nabuphine Combined with Ciprofol or Propofol in Painless Gastrointestinal Endoscopy in Patients with Coronary Heart Disease

作　　者：翟晓阳 付晗妤 王清洋 ZHAI Xiaoyang;FU Hanyu;WANG Qingyang(Department of Endoscopy Centery,Fuwai Central China Cardiovascular Hospital,Zhengzhou 450000,China;Department of Anesthesiology,Fuwai Central China Cardiovascular Hospital,Zhengzhou 450000,China)

机构地区：[1]阜外华中心血管病医院内镜中心,河南郑州450000 [2]阜外华中心血管病医院麻醉科,河南郑州450000

出　　处：《河南医学研究》2025年第5期825-829,共5页Henan Medical Research

基　　金：河南省医学科技攻关计划(联合共建)项目(LHGJ20210090)。

摘　　要：目的对比观察盐酸纳布啡复合环泊酚或丙泊酚用于冠心病患者无痛胃肠镜的麻醉效果。方法筛选阜外华中心血管病医院2021年2月至2023年2月接受无痛胃肠镜检查的冠心病患者80例为研究对象,计算机随机数字生成程序分为盐酸纳布啡复合环泊酚组(H组)和盐酸纳布啡复合丙泊酚组(B组),每组40例。对比两组患者麻醉前5 min(T_(0))、睫毛反射消失后(T_(1))、入镜时(T_(2))、退镜时(T_(3))、苏醒时(T_(4))的血流动力学指标包括心率(HR)、收缩压(SBP)、舒张压(DBP)和脉搏氧饱和度(SpO_(2));胃肠镜检查指标包括诱导时间、操作时间、苏醒时间、定向力恢复时间;不良反应和简易精神状态检查量表(MMSE)。结果H组和B组在对心率、收缩压和舒张压的影响方面差异有统计学意义(P<0.05);两组心率、收缩压、舒张压和氧饱和度4个指标在不同时间的整体差异无统计学意义(P>0.05);心率、收缩压、舒张压和氧饱和度4个指标的时间点与分组之间均存在交互效应(P<0.001)。两组的心率、收缩压和舒张压在T_(2)和T_(3)均低于基础时点T_(0)(P<0.05),并且在相同时点B组相应指标均低于H组(P<0.001)。H组诱导时间和定向力恢复时间均短于B组(P<0.05),H组苏醒延迟发生率低于B组(P<0.05)。两组不良反应发生情况和检查前后的MMSE评分差异无统计学意义(P>0.05)。结论冠心病患者行无痛胃肠镜检查中使用纳布啡复合环泊酚比纳布啡复合丙泊酚更有助于血流动力学平稳,麻醉效果更好,不良反应发生率更低。Objective To compare the anesthesia effect of nalbuphine combined with ciprofol or propofol in painless gastrointestinal endoscopy in patients with coronary heart disease.Methods A total of 80 patients with coronary heart disease who underwent painless gastroenteroscopy in Fuwai Central China Cardiovascular Hospital from February 2021 to February 2023 were selected as the study objects,and the computer random program was divided into nalbuphine hydrochloride combined ciprofol group(H group)and nalbuphine hydrochloride combined propofol group(B group),with 40 cases in each group.The hemodynamic indexes[heart rate(HR),systolic blood pressure(SBP),diastolic blood pressure(DBP)and pulse oximetry(SpO_(2))],gastroscopy indexes[induction time,operation time,awakening time,orientation recovery time],adverse reactions and simple mental status examination scale(MMSE)were compared between the two groups at 5 minues(T_(0))before anesthesia,after the eyelash reflex disappeared(T_(1)),the time of admission(T_(2)),the time of retreat(T_(3)),and the time of awakening(T_(4)).Results There were significant differences between group H and group B in terms of heart rate,systolic blood pressure and diastolic blood pressure(P<0.05).There were no significant differences in heart rate,systolic blood pressure,diastolic blood pressure and oxygen saturation between the two groups at different times(P>0.05).There were interaction effects between time points and groups of the above four indicators(P<0.001).The heart rate,systolic blood pressure and diastolic blood pressure of both groups were lower than those at T_(2)and T_(3)(P<0.05),and the corresponding indexes in group B were lower than those in group H at the same time point(P<0.001).The induction time and directional recovery time of group H were shorter than those of group B,and there were statistical differences between the two groups(P<0.05),and the incidence of delayed awakening in group H was lower than that in group B(P<0.05).There was no significant difference in the occurrence

关 键 词：环泊酚 丙泊酚 纳布啡 无痛胃肠镜 

分 类 号：R641.2[医药卫生—外科学]