术中超声辅助显微切除术治疗脑胶质瘤的效果及神经功能预后研究  

Effect of Intraoperative Ultrasound-Assisted Microsurgery in the Treatment of Glioma and the Prognosis of Neurological Function

作　　者：胡国强[1] 史霄汉 HU Guoqiang;SHI Xiaohan(Neurosurgery Department,Anyang People’s Hospital,Anyang 455000,China)

机构地区：[1]安阳市人民医院神经外科,河南安阳455000

出　　处：《河南医学研究》2025年第5期861-865,共5页Henan Medical Research

摘　　要：目的探讨术中超声辅助显微切除术治疗脑胶质瘤患者的效果。方法选取2019年3月至2023年3月安阳市人民医院收治的脑胶质瘤患者60例,根据手术方案分为对照组(30例)、观察组(30例)。对照组接受常规显微切除术,观察组在对照组的基础上接受术中超声辅助治疗。比较两组手术指标、临床疗效、神经肽水平、神经功能和认知功能、生活能力及预后。结果观察组手术出血量低于对照组,手术时长短于对照组,肿瘤切除程度高于对照组(P<0.05)。观察组总有效率高于对照组(P<0.05)。观察组术后3个月美国国立卫生研究院卒中量表(NIHSS)评分低于对照组,而精氨酸升压素(AVP)、催产素(OT)、β-内啡肽(β-EP)水平、简易精神状态量表(MMSE)评分及均日常生活能力量表(ADL)评分高于对照组(P<0.05)。术后1 a内观察组复发率低于对照组,生存率高于对照组(P<0.05)。结论在常规显微切除术的基础上,联合术中超声辅助治疗脑胶质瘤患者,可改善患者手术指标,提高临床疗效,调节神经肽水平,减轻神经功能损害,保护认知功能,改善日常活动能力及生存预后,值得临床推广应用。Objective To explore the effect of intraoperative ultrasound-assisted microsurgery in the treatment of patients with glioma.Methods From March 2019 to March 2023,60 patients with glioma in Anyang People’s Hospital were selected and divided into control group(30 cases)and observation group(30 cases)according to surgical schemes.The control group received conventional microsurgery,and the observation group received intraoperative ultrasound-assisted treatment on the basis of the control group.Surgical indexes,clinical efficacy,neuropeptide levels,neurological and cognitive functions,living ability and long-term prognosis between the two groups were compard.Results The amount of surgical bleeding in the observation group were lower than that in the control group,and duration of surgery in the observation group were shorter than that in the control group,and the degree of tumor resection was higher than that in the control group(P<0.05).The total effective rate of the observation group was higher than that of the control group(P<0.05).The National Institutes of Health stroke scale(NIHSS)score of the observation group was lower than that of the control group at 3 months after surgery,while the levels of arginine vasopressin(AVP),oxytocin(OT),β-endorphin(β-EP),the score of the measured mental state exercise(MMSE),and the activity of daily living(ADL)score were higher than that of the control group(P<0.05).The recurrence rate of the observation group was lower than that of the control group and the survival rate was higher than that of the control group in the 1-year postoperative period(P<0.05).Conclusion On the basis of conventional microsurgery,combined with intraoperative ultrasound-assisted treatment of patients with glioma,it can improve patients’surgical indicators,improve clinical efficacy,regulate neuropeptide levels,reduce neurological damage,protect cognitive function,improve daily activities and survival prognosis,and is worthy of clinical application.

关 键 词：脑胶质瘤 术中超声 显微切除术 疗效 神经功能 生活能力 预后 

分 类 号：R587.1[医药卫生—内分泌]