血清CXCL12、CCCK-18、GDF-15与急性心肌梗死患者再灌注损伤的关系  

Correlation Between Serum CXCL12,CCCK-18,GDF-15 and Reperfusion Injury in Patients with Acute Myocardial Infarction

作　　者：孙娜娜 朱彩虹[1] SUN Nana;ZHU Caihong(Department of Cardiology,the Seventh People’s Hospital of Zhengzhou,Zhengzhou 450000,China)

机构地区：[1]郑州市第七人民医院心内科,河南郑州450000

出　　处：《河南医学研究》2025年第5期865-868,共4页Henan Medical Research

摘　　要：目的探讨血清通道传送控制趋化因子配体12(CXCL12)、细胞角蛋白18裂解片段(CCCK-18)、生长分化因子15(GDF-15)与急性心肌梗死(AMI)患者再灌注损伤的相关性。方法将2022年1月至2024年1月在郑州市第七人民医院行经皮冠状动脉介入治疗(PCI)治疗的90例AMI患者纳入研究,根据患者是否出现再灌注损伤将其分为对照组(未出现再灌注损伤,62例)和观察组(出现再灌注损伤,28例)。比较两组一般资料和血清CXCL12、CCCK-18、GDF-15水平;采用单因素分析、二元logistic回归分析法分析影响AMI患者PCI术后再灌注损伤发生的独立危险因素;使用受试者工作特征(ROC)曲线评估血清CXCL12、CCCK-18、GDF-15水平预测AMI患者PCI术后再灌注损伤发生的临床价值。结果观察组年龄、B型脑钠肽、左心室射血分数、血清CXCL12、CCCK-18、GDF-15水平高于对照组(P<0.05);单因素分析、二元logistic回归分析结果显示血清CXCL12、CCCK-18、GDF-15水平是影响AMI患者PCI术后再灌注损伤发生的独立危险因素;ROC曲线分析结果显示CXCL12、CCCK-18、GDF-15水平预测AMI患者PCI术后再灌注损伤发生的最佳临界值分别为11.65μg·L^(-1)、246.80 U·L^(-1)、893.85 ng·L^(-1);此时曲线下面积分别为0.743、0.776、0.872(P<0.05);灵敏度分别为62.96%、74.07%、92.59%;特异度分别为87.10%、75.81%、62.90%。结论存在再灌注损伤的AMI患者PCI术后血清CXCL12、CCCK-18、GDF-15表达量上升,监测CXCL12、CCCK-18、GDF-15水平可有效预测AMI患者PCI术后再灌注损伤发生。Objective To investigate the correlation between serum channel transfer control chemokine ligand 12(CXCL12),caspase-cleaved cytokeratin 18(CCCK-18),growth differentiation factor 15(GDF-e15)and reperfusion injury in patients with acute myocardial infarction(AMI).Methods A total of 90 AMI patients who underwent percutaneous coronary intervention(PCI)in the Seventh People’s Hospital of Zhengzhou from January 2022 to January 2024 were included in the study.According to the presence or absence of reperfusion injury after treatment,the patients were divided into control group(without reperfusion injury,62 cases)and observation group(with reperfusion injury,28 cases).The general data and serum levels of CXCL12,CCCK-18 and GDF-15 were compared between the two groups.Univariate analysis and binary logistic regression analysis were used to analyze the independent risk factors affecting the occurrence of reperfusion injury in AMI patients after PCI.Receiver operating characteristic(ROC)curve was used to evaluate the clinical value of serum CXCL12,CCCK-18 and GDF-15 levels in predicting the occurrence of reperfusion injury in AMI patients after PCI.Results The observation group had significantly higher age,B-type natriuretic peptide,left ventricular ejection fraction,and serum levels of CXCL12,CCCK-18,GDF-15 than the control group(P<0.05).Univariate analysis and binary logistic regression analysis showed that serum levels of CXCL12,CCCK-18 and GDF-15 were independent risk factors for reperfusion injury in AMI patients after PCI.ROC curve analysis showed that the optimal critical values of CXCL12,CCCK-18 and GDF-15 levels to predict reperfusion injury after PCI in AMI patients were 11.65μg·L^(-1),246.80 U·L^(-1),893.85 ng·L^(-1),the area under the curve was 0.743,0.776,0.872(P<0.05),the sensitivity was 62.96%,74.07%,92.59%,the specificity was 87.10%,75.81%,62.90%.Conclusion The serum levels of CXCL12,CCCK-18 and GDF-15 increase in AMI patients with reperfusion injury after PCI.Monitoring the levels of CXCL12,CCCK-18 and

关 键 词：急性心肌梗死 经皮冠状动脉介入治疗 再灌注损伤 通道传送控制趋化因子配体12 细胞角蛋白18裂解片段 生长分化因子15 

分 类 号：R543.3[医药卫生—心血管疾病]