容积旋转调强放疗对晚期非小细胞肺癌患者的效果  

Interventional Effect of Volume Rotation Intensity Modulated Radiotherapy on Advanced Non-small Cell Lung Cancer Patients

作　　者：范娟 秦宁 李东亮 FAN Juan;QIN Ning;LI Dongliang(Radiotherapy Department,Zhumadian Central Hospital,Zhumadian 463000,China;Oncology Department,Zhumadian 463000,China)

机构地区：[1]驻马店市中心医院放疗科,河南驻马店463000 [2]驻马店市中心医院肿瘤科,河南驻马店463000

出　　处：《河南医学研究》2025年第5期893-896,共4页Henan Medical Research

基　　金：吴阶平医学基金会临床科研专项资助基金(320.6750.2021-10-54)。

摘　　要：目的探讨容积旋转调强放疗对晚期非小细胞肺癌患者的干预效果。方法选取94例晚期非小细胞肺癌患者,随机分组。对照组患者采用适形调强放疗治疗,观察组患者采用容积旋转调强放疗治疗,两组患者在放疗的同时均采用多西他赛联合顺铂方案化疗,比较两组治疗效果。结果观察组客观缓解率及病情控制率分别为85.11%和95.74%,均略高于对照组的76.60%和87.23%,但两组间差异无统计学意义(P>0.05)。治疗过程中,观察组放射性肺炎发生率为27.66%,低于对照组的48.94%(P<0.05),观察组患者放射性食管炎及放射性心脏损伤发生率分别为55.32%和10.64%,对照组分别为59.57%和8.51%,组间比较,差异无统计学意义(P>0.05)。结论容积旋转调强放疗与适形调强放疗治疗晚期非小细胞肺癌患者均具有较好的疗效,但容积旋转调强放疗安全性相对较高,能够降低放射性肺炎发生率。Objective To explore the intervention effect of volume rotation intensity modulated radiotherapy on advanced non-small cell lung cancer patients.Methods A total of 94 patients with advanced non-small cell lung cancer were selected and randomly separated into groups.The control group was treated with static conformal intensity modulated radiation therapy,while the observation group was treated with volume rotation intensity modulated radiation therapy.Both groups were treated with Docetaxel+cisplatin chemotherapy at the same time as radiation therapy.The treatment effects of the two groups were compared.Results The objective remission rate and disease control rate of the observation group were 85.11%and 95.74%,respectively,which were slightly higher than 76.60%and 87.23%of the control group,however,there was no statistically obvious difference between the two groups(P>0.05).During the treatment process,the incidence of radiation pneumonia in the observation group was 27.66%,which was lower than 48.94%in the control group(P<0.05),the incidence of radiation esophagitis and radiation cardiac injury in the observation group were 55.32%and 10.64%,respectively,and those in the control group was 59.57%and 8.51%respectively,and there was no statistically obvious difference between the two groups(P>0.05).Conclusion Both volume rotational intensity modulated radiotherapy and conformal intensity modulated radiotherapy have good efficacy in the treatment of advanced non-small cell lung cancer patients,but volume rotational intensity modulated radiotherapy is relatively safe and can reduce the incidence of radiation pneumonia.

关 键 词：晚期非小细胞肺癌 容积旋转调强 适形调强 放疗 

分 类 号：R454[医药卫生—治疗学]