亚麻醉剂量艾司氯胺酮对胸腔镜下肺癌根治术患者术后疲劳的影响  

Effect of subanesthetic dose of esketamine on postoperative fatigue in patients undergoing thoracoscopic radical resection for lung cancer

作　　者：房芳 周俊辉[1] 钟巍[1] FANG Fang;ZHOU Junhui;ZHONG Wei(Department of Anesthesiology,He’nan Provincial Chest Hospital(Affiliated Chest Hospital of Zhengzhou University),Zhengzhou 450000,China)

机构地区：[1]河南省胸科医院/郑州大学附属胸科医院麻醉科,郑州450000

出　　处：《上海医药》2025年第2期34-38,共5页Shanghai Medical & Pharmaceutical Journal

基　　金：河南省科技攻关计划项目(212102310720);河南省科技研发计划联合基金资助项目(232103810054)。

摘　　要：目的:探讨亚麻醉剂量艾司氯胺酮对120例胸腔镜下肺癌根治术患者术后疲劳(POF)的影响。方法:将患者随机分成艾司氯胺酮组(E组)和舒芬太尼组(S组),每组60例。主要指标为疲劳程度评估量表(FSS)评分,次要指标为术后48h内不良事件发生率。测定术前1d及术后1、3d时血清肿瘤坏死因子-α(TNF-α)、白介素(IL)-6和IL-8浓度。结果:与S组比较,E组术后1、3、7d时FSS评分均降低(P<0.05);E组POF发生率低于S组(15.0%vs.38.3%,P<0.05)。与S组比较,E组术后1或3 d时血清TNF-α、IL-6和IL-8浓度及术后48 h内恶心呕吐发生率均降低(P<0.05)。结论:亚麻醉剂量艾司氯胺酮可抑制胸腔镜下肺癌根治术患者术后炎性反应,减轻POF。Objective:To investigate the effects of subanesthetic dose of esketamine on postoperative fatigue(POF)in 120 patients undergoing thoracoscopic radical surgery for lung cancer.Methods:The patients were randomly divided into an esketamine group(group E)and a sufentanil group(group S)with 60 patients each.The primary indicator was the fatigue severity scale(FSS)score and the secondary indicator was the incidence of adverse events within postoperative 48 hours.Serum concentrations of tumor necrosis factor-α(TNF-α),interleukin(IL)-6 and IL-8 were measured on the day 1 before surgery and the day 1 or 3 after surgery.Results:Compared with the group S,the FSS scores in the group E were significantly reduced on postoperative day 1,3 and 7(P<0.05);the incidence of POF was lower in the group E than the group S(15.0%vs.38.3%,P<0.05).Serum concentrations of TNF-α,IL-6,and IL-8 on postoperative day 1 or 3 and the incidence of nausea and vomiting within postoperative 48 hours were significantly lower in the group E compared with the group S(P<0.05).Conclusion:Subanesthetic dose of esketamine can inhibit postoperative inflammatory response and alleviate POF in patients undergoing thoracoscopic radical surgery for lung cancer.

关 键 词：艾司氯胺酮 术后疲劳 胸腔镜手术 肺癌 炎性反应 

分 类 号：R971.2[医药卫生—药品] R614.2[医药卫生—药学]