基于多导睡眠监测技术评价柴胡加龙骨牡蛎汤对急性脑梗死后睡眠障碍(肝郁化火证)的临床疗效  

Clinical efficacy of Chaihu plus Longgu Muli decoction on sleep disorders(liver Qi stagnation turning into fire syndrome)after acute cerebral infarction based on polysomnography technology

作　　者：王冉 高松 王新 WANG Ran;GAO Song;WANG Xin(Department of Neurology,Huairou Hospital,Beijing Hospital of Traditional Chinese Medicine,Beijing 101400,China)

机构地区：[1]北京中医医院怀柔医院脑病科,北京101400

出　　处：《上海医药》2025年第2期47-50,共4页Shanghai Medical & Pharmaceutical Journal

基　　金：北京市怀柔区卫生和计划生育委员会科研项目(2018-C-001)。

摘　　要：目的:探究基于多导睡眠监测(PSG)技术评价柴胡加龙骨牡蛎汤对急性脑梗死(ACI)后睡眠障碍(肝郁化火证)的临床疗效。方法:将ACI后睡眠障碍患者92例随机分为对照组和观察组,各46例。对照组予以常规治疗方案,观察组在对照组的基础上予以柴胡加龙骨牡蛎汤治疗,疗程4周,比较两组疗效。结果:治疗后,观察组总有效率、睡眠效率高于对照组;失眠程度指数、匹兹堡睡眠质量指数、微觉醒指数评分、觉醒次数低于对照组;睡眠总时间长于对照组;入睡时间短于对照组(P<0.05);两组不良反应比较,差异无统计学意义(P>0.05)。结论:柴胡加龙骨牡蛎汤应用于ACI后睡眠障碍患者中,能够减轻患者失眠程度,改善睡眠质量、睡眠效率及PSG指标,提高疗效。Objective:To investigate the clinical efficacy of Chaihu plus Longgu Muli decoction on sleep disorders(liver Qi stagnation turning into fire syndrome)after acute cerebral infarction(ACI)using polysomnography(PSG).Methods:A total of 92 patients with sleep disorders after ACI were randomly divided into a control group and an observation group with 46 cases each.The control group received conventional treatment,while the observation group was treated with Chaihu plus Longgu Muli decoction on the basis of the control group,with a treatment course of 4 weeks.The efficacy of the two groups was compared.Results:After treatment,the total effective rate and sleep efficiency were higher,and the insomnia severity index,Pittsburgh sleep quality index,micro-arousal index,and the times of awakenings were lower in the observation group than the control group.The total sleep time was longer and the sleep onset time was shorter in the observation group than the control group(P<0.05).There were no significant differences in adverse reactions between the two groups(P>0.05).Conclusion:Chaihu plus Longgu Muli decoction for the treatment of the patients can reduce the severity of insomnia,improve sleep quality,sleep efficiency,PSG indicators and therapeutic effects.

关 键 词：急性脑梗死 睡眠障碍 柴胡 龙骨牡蛎汤 多导睡眠监测 

分 类 号：R289.5[医药卫生—方剂学] R256.23[医药卫生—中药学]