Quantitative imaging of dynamic myocardial blood flow using dual‐head rapidly rotating gantry single‐photon emission computed tomography to enhance coronary artery disease diagnosis  

作　　者：Yongli Bai Bingyue Bai Gang Miao Wenzhi Wang Longmei Wang Dan Ma Wenjing Shi 

机构地区：[1]Department of Nuclear Medicine,Shaanxi Provincial People's Hospital,Xi'an,Shaanxi,China

出　　处：《iRADIOLOGY》2024年第3期305-317,共13页融合影像学(英文)

基　　金：Shaanxi Province key research and development plan,Grant/Award Number:S2024‐YF‐YBSF‐0395。

摘　　要：Background:This study aimed to evaluate the performance of myocardial blood flow(MBF)and myocardial flow reserve(MFR)for diagnosing coronary artery disease(CAD)using dynamic single‐photon emission computed to-mography/computed tomography(SPECT/CT)with a dual‐head rapidly rotating gantry(RRG)and to compare this method with conventional myocardial perfusion imaging(MPI),which can be obtained in a one‐stop manner.Methods:A total of 93 patients with suspected or confirmed CAD who un-derwent RRG SPECT/CT were retrospectively enrolled.They underwent invasive coronary angiography(ICA)and conventional MPI within 3 weeks.Based on the ICA results,the performance of MBF quantitative and semi‐quantitative parameters were compared at patient and vessel levels using≥50%and≥75%stenosis as the criteria for CAD diagnosis.Receiver operating characteristic(ROC)curve was used to evaluate the diagnostic efficacy of two types of parameters.Results:For patient‐level analysis,the area under ROC curves(AUCs)for stress MBF(sMBF),MFR,summed stress score(SSS),and summed different score(SDS)were 0.971,0.939,0.612,and 0.546,respectively,for≥50%stenosis as positive,and were 0.983,0.932,0.735,and 0.509,respectively,for≥75%stenosis as positive criteria.For vessel‐level analysis,the AUCs of sMBF,MFR,SSS,and SDS were 0.981,0.933,0.636,and 0.560,respectively,for≥50%stenosis as positive and were 0.984,0.933,0.767,and 0.583,respectively,for≥75%stenosis as positive criteria.Conclusions:Compared with semi‐quantitative parameters of conventional MPI,MBF quantitative parameters of dual‐head RRG SPECT had higher diagnostic performance for CAD.

关 键 词：CAD dual‐head rapid rotating GANTRY (RRG) SPECT MULTIVESSEL disease MYOCARDIAL blood FLOW MYOCARDIAL FLOW reserve MYOCARDIAL ischemia quantitative 

分 类 号：R54[医药卫生—心血管疾病]