Qualitative and quantitative imaging of alpha‐emitting radiopharmaceuticals  

作　　者：Lan Wang Jingjing Lou Xuecen Cao Lina Jia Shuai Xue Xingdang Liu Lan Zhang Xiao Li 

机构地区：[1]Department of Nuclear Medicine,Pudong Hospital,Fudan University,Shanghai,China [2]Department of Nuclear Medicine,Huashan Hospital,Fudan University,Shanghai,China [3]Shanghai Institute of Applied Physics,Chinese Academy of Sciences,Shanghai,China

出　　处：《iRADIOLOGY》2024年第4期396-411,共16页融合影像学(英文)

基　　金：Pudong Hospital,Fudan University,College Project,Grant/Award Numbers:YJYJRC202108,YJYJRC202101,Zdzk2020‐14;Pudong New Area Clinical Characteristic Discipline Project,Grant/Award Number:PWYts2021‐01;National Natural Science Foundation of China,Grant/Award Number:82272042;Clinical research program of Health Industry of Shanghai Municipal Commission of Health,Grant/Award Number:202150002;Shanghai Science and Technology Commission Project:Molecular imaging study on mild cognitive impairment,Grant/Award Number:17411950102;National Key Research and Development Plan Digital Diagnosis and Treatment Equipment Research and Development Project:Research and Practice of PET‐CT Comprehensive Evaluation System and Training System,Grant/Award Number:2017YFC0113300。

摘　　要：Targeted alpha(α)therapy(TAT)is an emerging therapeutic strategy for cancer treatment.To evaluate the safety and efficacy of targetedα‐therapy,the biodistribution and internal radiation dose ofα‐emitting radionuclides should be determined.In vivo imaging of these radionuclides often involves the detection of gamma rays,X‐rays,and positrons generated during their complex decay processes.This review aims to classify theα‐emitting radionuclides(astatine‐211,actinium‐225,radium‐223,bismuth‐212,bismuth‐213,thorium‐227,and terbium‐149)according to their imageable signals.Additionally,this study summarizes various imaging modalities,including gamma camera im-aging,single‐photon emission computed tomography,positron emission to-mography,Compton imaging,bremsstrahlung imaging,and Cerenkov luminescence imaging,which hold potential for imagingα‐emitting radionu-clides,to explore their biomedical applications in qualitative nuclide tracing and diagnosis,quantifying pharmacokinetics,and assessing prognosis and response to therapy.

关 键 词：alpha‐emitting radionuclide qualitative imaging quantitative imaging targeted alpha therapy 

分 类 号：O57[理学—粒子物理与原子核物理]