Selective pyrophosphate detection via metal complexes  

作　　者：Xiao Zhang Wenwen Sun Le Wang Zeping Xie Mengxia Liu Junfeng Wang 

机构地区：[1]College of Chemistry and Chemical Engineering,Shanghai University of Engineering Science,Shanghai,China [2]Gordon Center for Medical Imaging,Massachusetts General Hospital and Harvard Medical School,Boston,Massachusetts,USA

出　　处：《iRADIOLOGY》2023年第4期320-339,共20页融合影像学(英文)

基　　金：NIH,Grant/Award Number:K25AG061282;Botanical Garden,Grant/Award Number:PFGR202304。

摘　　要：Pyrophosphate(PPi)anions are crucial in numerous biological and ecological processes involved in energy conversion,enzymatic reactions,and metabolic regulation along with adenosine.They are also significant biological markers for various processes related to diseases.Fluorescent PPi sensors would enable visual and/or biological detection in convenient settings.However,the current availability of commercial sensors has been limited to costly enzymes that are not compatible for imaging.Sensor development has also encountered challenges such as poor selectivity and stability and limited practical applications.In this review,we analyze the situation of PPi sensing via commercial kits and focus on sensors that use metal complexes.We address their designs,sensing mechanisms,selectivities,and detection limits.Finally,we discuss limitations and perspectives for PPi detection and imaging.

关 键 词：FLUORESCENCE imaging metal complex pyrophosphate(PPi) SENSOR 

分 类 号：O62[理学—有机化学]