轻度认知功能障碍高低阶耦合网络特征分析  

Characteristics of High and Low Order Coupled Networks in Mild Cognitive Dysfunction

作　　者：甄浩延 徐佳森 李梓澎 李昕[1,2] ZHEN Haoyan;XU Jiasen;LI Zipeng;LI Xin(School of Electrical Engineering,Yanshan University,Qinhuangdao,Hebei 066004,China;Measurement Technology and Instrumentation Key Lab of Hebei Province,Qinhuangdao,Hebei 066004,China)

机构地区：[1]燕山大学电气工程学院,河北秦皇岛066004 [2]河北省测试计量技术及仪器重点实验室,河北秦皇岛066004

出　　处：《计量学报》2025年第2期287-297,共11页Acta Metrologica Sinica

基　　金：河北省自然科学基金(F2019203515,F2022203005);河北省科技计划(236Z2004G);燕山大学与秦皇岛市第一医院医工交叉特色(UY202201)。

摘　　要：针对轻度认知功能障碍患者(MCI)脑功能连接异常问题,提出了一种新的高低阶耦合脑功能网络构建方法。基于皮尔逊相关,在分析不同脑区功能相关与同步基础上,构建脑区之间的高阶耦合网络,并分析高低阶耦合网络特征、小世界属性、rich-club系数以及网络的稳定性等重要脑功能网络特征标记。研究结果表明:相较于阿尔茨海默病患者(AD)对照组,MCI组的delta频段其脑网络连接连接强度,全局效率和聚类系数均有显著下降(P<0.05)。分析功能网络核心节点发现AD组和MCI组在各网络下的核心节点数均少于正常(HC)组,MCI组核心节点主要分布在前额叶,AD核心节点主要分布在顶叶和枕叶,在beta和delta频段AD组相较于HC组的核心节点易损性显著提高(P<0.05),而在beta和theta频段中,MCI组的核心节点易损性显著大于HC组(P<0.05)。上述结果说明:高低阶耦合网络特征可以有效地表达轻度认知障碍脑功能状态,将为轻度认知障碍早期诊断提供帮助。For the problem of abnormal brain functional connectivity in patients with mild cognitive impairment(MCI),a new method of constructing high-and low-order coupled brain functional networks was proposed.Based on Pearson's correlation,the higher-order coupling network between brain regions was constructed on the basis of analyzing the functional correlation and synchronization of different brain regions,and important brain functional network feature markers such as high-and low-order coupling network characteristics,small-world properties,rich-club coefficients,and the stability of the network were analyzed.The results of the study showed that compared with the Alzheimer's disease(AD)control group,the delta frequency band of the MCI group had a significant decrease in its brain network connectivity connection strength,global efficiency and clustering coefficient(P<0.05).Analyzing the core nodes of the functional network found that both AD and MCI groups had fewer core nodes than the normal(HC)group under each network,the core nodes of the MCI group were mainly distributed in the prefrontal lobe,and the core nodes of AD were mainly distributed in the parietal and occipital lobe,and the core node vulnerability of the AD group was significantly higher(P<0.05)compared to the HC group in the beta and delta frequency bands,whereas the core node vulnerability of the MCI group was significantly higher(P<0.05)than the normal(HC)group in the beta and theta bands,the core node susceptibility of MCI group was significantly larger than that of HC group(P<0.05).The above results suggest that the high-and low-order coupled network features can effectively express the functional state of the brain in mild cognitive impairment,which will be helpful for the early diagnosis of mild cognitive impairment.

关 键 词：生物计量 轻度认知功能障碍 脑功能网络 高低阶耦合 RICH-CLUB 介数中心度 

分 类 号：TB99[一般工业技术—计量学] TB973[机械工程—测试计量技术及仪器]