前S1抗原 乙型肝炎病毒DNA联合乙型肝炎5项检验用于乙型肝炎肝纤维化诊断的价值  

The value of the pre-S1 antigen,hepatitis B virus-DNA combined with the hepatitis B 5-indicators test for the diagnosis in hepatitis B liver fibrosis

作　　者：黄海艳 Huang Haiyan(Department of Laboratory,Pingdingshan City Hospital of Traditional Chinese Medicine,Pingdingshan 467099,China)

机构地区：[1]平顶山市中医医院检验科,平顶山467099

出　　处：《实用医技杂志》2025年第2期134-138,共5页Journal of Practical Medical Techniques

摘　　要：目的探究前S1抗原、乙型肝炎病毒脱氧核糖核酸(HBV-DNA)联合乙型肝炎5项检验在乙型肝炎肝纤维化中的检验效果。方法选取本院2021年8月至2023年2月120例乙型肝炎患者作为研究对象,对入院患者进行前S1抗原、HBV-DNA、乙型肝炎5项检验[乙型肝炎表面抗原(HBsAg)、乙型肝炎e抗原(HBeAg)、乙型肝炎核心抗体(HBcAb)、乙型肝炎表面抗体(HBsAb)、乙型肝炎e抗体(HBeAb)],以肝组织病理学活检结果作为诊断纤维化的金标准,探究各项指标的诊断效能。结果纳入的120例患者中,有41例患者未出现肝纤维化,占比为34.2%,作为未发生组;有79例患者出现肝纤维化,占比为65.8%,作为发生组。2组HBeAb、HBsAb水平对比差异无统计学意义(P>0.05);2组HBsAg、HBeAg、HBcAb、HBV-DNA、前S1抗原水平对比差异有统计学意义(P<0.05);各单一诊断与联合诊断受试者工作特征曲线下面积(AUC)值均>0.7,其中联合诊断价值更高。结论在乙型肝炎肝纤维化疾病诊断中,联合前S1抗原、HBV-DNA、乙型肝炎5项指标,较单一诊断方法效能更高,可推广。Objective To explore the effect of the pre-S1 antigen,hepatitis B virus(HBV)-DNA and hepatitis B 5-indicators for the diagnosis in hepatitis B liver fibrosis.Methods In 120 patients with hepatitis B from August 2021 to February 2023,hepatitis pre-S1 antigen HBV-DNA and hepatitis B 5-indicators(HBsAg,HBeAg,HBcAb,HBsAb,HbeAb).Using liver tissue pathological biopsy as the gold standard for diagnosing fibrosis,explore the diagnostic efficacy of the above indicators.Results Among the 120 patients included,41 patients did not experience liver fibrosis,accounting for 34.2%,and were included as the non occurring group;79 patients,accounting for 65.8%,developed liver fibrosis as the occurrence group.There were no statistically significant difference in the levels of HBeAb and HBsAb between the two groups(P>0.05).There were statistically significant difference in the levels of HBsAg,HBeAg,HBcAb,HBV-DNA,and pre S1 antigens between the two groups(P<0.05).The AUC values for both single and combined diagnoses are greater than 0.7,with the combined diagnosis having a higher value.Conclusion In the diagnosis of hepatitis B liver fibrosis disease,the combi-nation of s pre-S1 antigen,HBV-DNA and hepatitis B 5-indicators are more effective than a single diagnostic method and can be popularized.

关 键 词：乙型肝炎病毒 DNA 乙型肝炎表面抗原 乙型肝炎E抗原 乙型肝炎抗体 肝纤维化 前S1抗原 

分 类 号：R51[医药卫生—内科学]