臭氧短期暴露对人群心血管健康及相关表观遗传标志物的影响  

Progress in research into the effects of short-term ozone exposure on cardiovascular health and related epigenetic markers in the population

作　　者：姜云星 白丽君[1,2] 吴少伟 JIANG Yunxing;BAI Lijun;WU Shaowei(Department of Occupational and Environmental Health,School of Public Health,Ministry of Education,Xi'an Jiaotong University,Xi'an 710061,China;Key Laboratory of Environment and Genes Related to Diseases(Xi'an Jiaotong University),Ministry of Education,Xi'an Jiaotong University,Xi'an 710061,China)

机构地区：[1]西安交通大学公共卫生学院,劳动卫生与环境卫生学系,陕西西安710061 [2]西安交通大学环境与疾病相关基因教育部重点实验室,陕西西安710061

出　　处：《兰州大学学报(医学版)》2025年第1期12-25,共14页Journal of Lanzhou University(Medical Sciences)

基　　金：国家重点研发计划项目(2022YFC3702604)。

摘　　要：臭氧(O_(3))是一种强氧化性污染物,其浓度随全球变暖上升,短期暴露可能增加急性心血管事件风险。本文综述了O_(3)短期(急性)暴露对心血管健康影响的研究进展,包括O_(3)对心血管疾病发病及死亡风险、ST段压低、心率变异性和血压变化等表型指标,以及表观遗传标志物的影响,旨在为O_(3)致心血管健康危害的机制研究和防控提供科学依据。Ozone(O_(3)),a highly oxidative ambient gaseous pollutant,is exhibiting an increasing concentration trend in the context of global warming and short-term O_(3)exposure has been associated with increased risks of acute cardiovascular events.This review summarized the research progress regarding the effects of short-term(including acute)O_(3)exposure on cardiovascular health in populations,including its effects on the morbidity and mortality risk of cardiovascular disease,as well as on cardiovascular health phenotype indicators,such as ST-segment depression,heart rate variability,blood pressure,and cardiovascular health-related epigenetic biomarkers.The aim was to provide a scientific basis for understanding the mechanisms and developing strategies to mitigate the harmful cardiovascular effects posed by O_(3)pollution.

关 键 词：臭氧 心血管疾病 心率变异性 ST段压低 表观遗传标志 

分 类 号：R122[医药卫生—环境卫生学]