乳腺癌钼靶影像学特征及其与微血管密度的相关性分析  

Mammographic imaging features of breast cancer and its correlation with microvascular density

作　　者：马利芹 刘丽[2] 胡恒利 陈玉雷 陈龙舟 韩志刚 MA Li-qin;LIU Li;HU Heng-li;CHEN Yu-lei;CHEN Long-zhou;HAN Zhi-gang(Department of Radiology,Huai'an Maternal and Child Health Care Hospital Affiliated to School of Medicine of Yangzhou University,Huai'an Jiangsu 223002,China;Department of Radiology,Xinjiang Production and Construction Corps 7th Division Hospital,Yili Xinjiang 833200,China)

机构地区：[1]扬州大学医学院附属淮安市妇幼保健院放射科,江苏淮安223002 [2]新疆生产建设兵团第七师医院放射科,新疆伊犁833200

出　　处：《局解手术学杂志》2025年第3期258-262,共5页Journal of Regional Anatomy and Operative Surgery

基　　金：新疆生产建设兵团第七师胡杨河市财政科技计划项目(2023A10)。

摘　　要：目的分析乳腺癌钼靶影像学特征及其与微血管密度(MVD)的相关性。方法选取2019年1月至2022年12月于新疆生产建设兵团第七师医院就诊并经手术病理证实为乳腺癌的患者86例作为研究对象。根据修改后的布鲁姆理查森评分系统,将乳腺癌患者分为组织学Ⅰ级(n=22)、Ⅱ级(n=25)和Ⅲ级(n=39)。所有患者术前均完善钼靶影像学检查,术后均行免疫组化并计数MVD。采用Spearman秩相关分析不同组织学分级乳腺癌患者MVD与钼靶影像特征的相关性。结果乳腺癌病灶组织微血管阳性表达率为100%,每视野MVD计数为14~276条,平均(72.58±16.37)条,其中组织学Ⅰ~Ⅱ级的患者MVD计数为14~175条,平均(42.10±13.51)条;组织学Ⅲ级的患者MVD计数为22~276条,平均(93.82±22.17)条。组织学Ⅲ级患者MVD计数明显高于组织学Ⅰ~Ⅱ级,差异有统计学意义(t=19.627,P<0.001)。组织学Ⅲ级乳腺癌患者边缘不光整、毛刺征、腋窝淋巴结转移和细小颗粒钙化出现率均高于组织学Ⅰ~Ⅱ级,差异有统计学意义(P<0.05)。乳腺癌患者表现为边缘不光整、毛刺征、腋窝淋巴结转移和细小颗粒钙化时,其MVD计数均高于边缘光整、无毛刺征、无腋窝淋巴结转移和无细小颗粒钙化,与组织学分级呈正相关(P<0.05)。结论乳腺癌部分钼靶影像学特征可在一定程度上反映肿瘤血管生成情况,为疾病的治疗及预后提供重要参考,具有一定临床价值。Objective To investigate the mammographic imaging features of breast cancer and its correlation with microvascular density(MVD).Methods A total of 86 patients with breast cancer confirmed by surgical pathology in Xinjiang Production and Construction Corps 7th Division Hospital from January 2019 to December 2022 were selected as the research objects.According to the modified Bloom Richardson scoring system,the breast cancer patients were classified into histological gradeⅠ(n=22),gradeⅡ(n=25)and gradeⅢ(n=39).All patients underwent preoperative mammographic imaging examination.Immunohistochemistry staining was performed and MVD count was conducted after operation.Spearman rank correlation was used to analyze the correlation between MVD of breast cancer with different histological grades and mammographic imaging features.Results The microvascular positive expression rate of breast cancer lesions was 100%,the MVD counts per visual field were 14~276 vessels,with an average of(72.58±16.37)vessels,of which the MVD counts of patients with histological gradeⅠtoⅡwere 14 to 175 vessels,with an average of(42.10±13.51)vessels;the MVD counts of patients with histological gradeⅢwas 22~276 vessels,with an average of(93.82±22.17)vessels.The MVD counts of patients with histological gradeⅢwas significantly higher than that of patients with histological gradeⅠtoⅡ,with statistically significant difference(t=19.627,P<0.001).The incidences of irregular margin,spicular sign,axillary lymph node metastasis and fine particle calcification in patients with histological gradeⅢwere higher than those in patients with histological gradeⅠtoⅡ,with statistically significant difference(P<0.05).The MVD counts of breast cancer patients with irregular margin,spicular sign,axillary lymph node metastasis and fine particle calcification were higher than those of patients with smooth margin and without spicular sign,axillary lymph node metastasis or fine particle calcification,which was positively correlated with histological gra

关 键 词：乳腺癌 钼靶 影像学特征 微血管密度 相关性 

分 类 号：R445.4[医药卫生—影像医学与核医学]