异功散加味辅助治疗小儿功能性消化不良脾虚夹积证的临床价值  

Clinical Value of Modified Yigongsan in the Treatment of Children with Functional Dyspepsia with Syndrome of Malnutrition Due to Spleen Deficiency

作　　者：吴洁如 徐瑶琪 谢尚任 Wu Jieru;Xu Yaoqi;Xie Shangren(Wenzhou Central Hospital,Zhejiang Wenzhou 325000,China)

机构地区：[1]温州市中心医院,浙江温州325000

出　　处：《儿科药学杂志》2025年第3期10-13,共4页Journal of Pediatric Pharmacy

基　　金：温州市科学技术科研基金,编号Y20180733。

摘　　要：目的:探讨异功散加味对小儿功能性消化不良(FD)脾虚夹积证的辅助治疗作用及临床应用价值。方法:回顾性收集我院2020-2023年门诊接诊的FD患儿98例(FD组)和同期体检健康儿童90例(健康组)。按治疗方案将98例FD患儿分为对照组和观察组各49例。对照组采用多潘立酮混悬液+常规基础治疗,观察组在对照组治疗方案基础上加用异功散加味内服,疗程4周。治疗4周后对两组FD患儿的临床相关指标进行比较分析,比较治疗效果、FD相关症状与脾虚夹积证评分以及血清胃泌素-17(G-17)、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)水平。结果:治疗前,FD组血清G-17、PGⅠ、PGⅡ水平均低于健康组(P<0.01)。治疗4周后,观察组总有效率为93.88%,高于对照组的77.55%(P<0.05);两组FD相关症状与脾虚夹积证评分均降低,且观察组均低于对照组(P均<0.01);两组血清G-17、PGⅠ、PGⅡ水平均升高,且观察组高于对照组(P<0.01)。结论:异功散加味对小儿FD脾虚夹积证的疗效显著,能改善FD相关症状与中医证候,上调血清G-17、PGⅠ、PGⅡ水平,值得临床推广应用与深入研究。Objective:To probe into the treatment efficacy and clinical value of modified Yigongsan in the treatment of children with functional dyspepsia(FD)with syndrome of malnutrition due to spleen deficiency.Methods:Retrospective analysis was performed on 98 FD children(FD group)admitted into outpatient department of Wenzhou Central Hospital from 2020 to 2023 and 90 healthy children in the same period(normal group).According to different treatment regimens,98 FD children were divided into the control group and observation group,with 49 cases in each group.The control group was treated with domperidone suspension+conventional basic treatment,while the observation group additionally received Yigongsan based on the control group,the treatment course was 4 weeks.After 4 weeks of treatment,the clinical related indicators of two groups with FD were compared and analyzed.The therapeutic effect,FD-related symptoms and spleen deficiency syndrome score,and the levels of serum gastrin-17(G-17),pepsinogenⅠ(PG-Ⅰ)and pepsinogenⅡ(PG-Ⅱ)were compared.Results:Before treatment,serum G-17,PG-Ⅰand PG-Ⅱlevels in FD group were lower than those in normal group(P<0.01).After 4 weeks of treatment,the total effective rate of observation group was 93.88%,higher than 77.55%of control group(P<0.05).The scores of FD-related symptoms and spleen-deficiency syndrome decreased in both groups,and the observation group was lower than the control group(P<0.01).Serum G-17,PG-Ⅰand PG-Ⅱlevels increased in both groups,and the observation group was higher than the control group(P<0.01).Conclusion:The efficacy of Yigongsan in the treatment of FD with syndrome of malnutrition due to spleen deficiency is evident,which can improve the the clinical symptoms and traditional Chinese medicine syndrome,up-regulate serum levels of G-17,PGⅠand PGⅡ,and is worthy of clinical application.

关 键 词：异功散 功能性消化不良 胃泌素-17 胃蛋白酶原Ⅰ 胃蛋白酶原Ⅱ 

分 类 号：R725.7[医药卫生—儿科]