玉屏风颗粒防治婴幼儿反复喘息的应用价值  

Application Value of Yupingfeng Granules in the Prevention and Treatment of Recurrent Wheezing in Infants

作　　者：方海龙 高运金 方勇 陈萍 廖志辉 刘鹏 Fang Hailong;Gao Yunjin;Fang Yong;Chen Ping;Liao Zhihui;Liu Peng(The Sixth People’s Hospital of Huizhou,Guangdong Huizhou 516211,China)

机构地区：[1]惠州市第六人民医院,广东惠州516211

出　　处：《儿科药学杂志》2025年第3期21-24,共4页Journal of Pediatric Pharmacy

摘　　要：目的:评估玉屏风颗粒防治婴幼儿反复喘息的潜在效果和安全性。方法:回顾性分析2018年10月至2020年10月在我院就诊的96例反复喘息婴幼儿的临床资料。患儿根据治疗方法分为两组:对照组48例采用常规吸入性糖皮质激素(ICS)治疗,而研究组48例则口服玉屏风颗粒。对两组患儿的基线资料、治疗前后喘息发作次数、治疗时间、静脉输液次数以及肺功能指标进行比较分析。结果:研究组在减少婴幼儿喘息发作次数、缩短治疗时间和减少静脉输液需求方面显示出与对照组相似的疗效;两组患儿治疗后的肺功能指标如潮气量(VT/kg)、达峰时间比(TPTEF/TE%)、达峰容积比(VPEF/VE%)和吸呼比(Ti/Te)比较,差异均无统计学意义(P均>0.05)。结论:玉屏风颗粒作为一种非激素治疗药物,为婴幼儿反复喘息的预防和管理提供了一种新的选择,其疗效与ICS吸入治疗相当,可能为不愿意或不能使用ICS治疗的家庭提供一个替代方案。Objective:To evaluate the potential effect and safety of Yupingfeng granules in the prevention and treatment of recurrent wheezing in infants.Methods:Retrospective analysis was performed on clinical data of 96 infants with recurrent wheezing admitted into our hospital from Oct.2018 and Oct.2020.The children were divided into two groups according to different treatment method:the control group(48 cases)received conventional inhaled glucocorticoids(ICS),while the study group(48 cases)was given oral Yupingfeng granules.Baseline data,frequency of wheezing episodes before and after treatment,treatment duration,intravenous fluid requirements,and pulmonary function indicators were compared between two groups.Results:The study group showed similar efficacy to the control group in reducing the number of wheezing episodes,shortening the treatment duration,and reducing the intravenous fluid requirements in infants.Additionally,there were no significant differences in pulmonary function indicators including tidal volume(VT/kg),ratio of time to peak tidal expiratory flow to total expiratory time(TPTEF/TE%),ratio of peak expiratory flow to minute ventilation(VPEF/VE%),and ratio of inspiratory to expiratory time(Ti/Te)between two groups after treatment(P>0.05).Conclusion:As a non-ICS therapy,Yupingfeng granules provide a new treatment option for prevention and treatment of recurrent wheezing in infants.The efficacy is comparable to ICS inhalation therapy and may serve as an alternative for families unwilling or unable to use ICS therapy.

关 键 词：玉屏风颗粒 吸入性糖皮质激素 婴幼儿 反复喘息 气道高反应性 肺功能 

分 类 号：R725.6[医药卫生—儿科]