间苯三酚对绝经后患者宫腔镜术前宫颈软化的有效性和安全性  

Efficacy and safety of triphenylphenol for the cervical softening of postmenopausal patients before hysteroscopy

作　　者：嵇玉芹 刘海燕 JI Yuqin;LIU Haiyan(Nanjing Qiaia District Hospital,Nanjing,Jiangsu Province,210046)

机构地区：[1]江苏省南京市栖霞区医院,210046

出　　处：《中国计划生育学杂志》2025年第3期568-571,共4页Chinese Journal of Family Planning

摘　　要：目的:分析间苯三酚对绝经后患者宫腔镜术前宫颈软化的有效性和安全性。方法:选取2021年1月-2024年6月本院妇科拟行宫腔镜手术治疗的绝经后患者80例,随机综合平衡法均分成观察组和对照组各40例,术前应用观察组间苯三酚,对照组采用米索前列醇常规处理,对比两组宫颈软化情况、并发症(宫颈裂伤、子宫穿孔等)、疼痛及手术情况。结果:观察组宫颈软化效果总有效率(92.5%)高于对照组(75.0%),用药后1h、3h、6h的疼痛评分(3.25±0.85分、4.10±1.30分、1.85±0.55分)均低于对照组(4.50±1.10分、5.20±1.40分、3.00±0.70分),并发症发生率(5.0%)低于对照组(32.5%),术中出血量(18.5±8.0ml)少于对照组(25.0±9.5ml),手术时间(6.5±2.0min)及宫颈扩张时间(28.0±10.0s)均短于对照组(8.8±2.5min、38.0±13.0s)(均P<0.05)。结论:间苯三酚在绝经后患者宫腔镜术前宫颈软化中具有较好的有效性和安全性。Objective:To analyze the efficacy and safety of triphenylphenol for the cervical softening of postmenopausal patients before hysteroscopy.Methods:80 postmenopausal patients who wanted the hysteroscopic surgery in the gynecology department of the hospital were selected and were randomly divided into observation group and control group(40 patients in each group)by the comprehensive balance method from January 2021 to June 2024.The patients in the observation group received the preoperative application of phloroglucinol,while the patients in the control group received the routine treatment.The cervical softening situation and the rate of the complications,such as the cervical laceration,uterine perforation,and so on,and the situations of pain and surgery of the patients were compared between the two groups.Results:The total effective rate of the cervical softening(92.5%)of the patients in the observation group was significantly higher than that(75.0%)of the patients in the control group.The pain scores of the patients in the observation group at 1h,3h,6h after treatment were 3.25±0.85 points,4.10±1.30 points and 1.85±0.55 points,respectively,and which were significantly lower than those(4.50±1.10 points,5.20±1.40 and 3.00±0.70 points)of the patients in the control group.The incidence of complications(5.0%)of the patients in the observation group was significantly lower than that(32.5%)of the patients in the control group.The intraoperative blood loss(18.5±8.0ml)of the patients in the observation group was significantly less than that(25.0±9.5ml)of the patients in the control group.The operation time(6.5±2.0min)and the cervical dilatation time(28.0±10.0s)of the patients in the observation group were significantly shorter than those(8.8±2.5min and 38.0±13.0s)of the patients in the control group(all P<0.05).Conclusion:Phloroglucinol has good efficacy and safety used for the cervical softening before hysteroscopy of the postmenopausal patients.

关 键 词：绝经后 宫腔镜手术 术前宫颈软化 间苯三酚 有效性 安全性 

分 类 号：R71[医药卫生—妇产科学]