子宫内膜异位症患者血清5-羟色胺、SP水平与临床分期、痛经程度关系  

Correlation between the serum 5-hydroxytryptamine and substance P levels of patients with endometriosis and their clinical stage of endometriosis and dysmenorrhea degree

作　　者：于迎新 李伟[2] 孟慧玲 孙志敏 周新 YU Yingxin;LI Wei;MENG Huiling;SUN Zhimin;ZHOU Xin(Cangzhou Maternal and Child Health Care Hospital,Cangzhou,Hebei Province,061000;Cangzhou Central Hospital,Cangzhou)

机构地区：[1]河北省沧州市妇幼保健院,061000 [2]河北省沧州市中心医院

出　　处：《中国计划生育学杂志》2025年第3期696-699,共4页Chinese Journal of Family Planning

基　　金：2021年度中医药类科研计划项目(2021357)。

摘　　要：目的:探讨子宫内膜异位症(EMT)患者血清5-羟色胺(5-HT)、P物质(SP)水平与临床分期、痛经程度的关系。方法:将2021年10月-2023年9月本院收治的97例EMT患者作为研究对象,根据临床分期分为Ⅰ期组(n=22)、Ⅱ期组(n=37)、Ⅲ期组(n=25)、Ⅳ期组(n=13),根据痛经程度分为无痛经组(n=11)、轻度痛经组(n=27)、中度痛经组(n=36)、重度痛经组(n=23)。比较不同临床分期、不同痛经程度的EMT患者血清5-HT、SP水平;Spearman相关分析血清5-HT、SP与EMT患者临床分期、痛经程度的相关性;受试者工作特性(ROC)曲线评估血清5-HT、SP对EMT患者临床分期(Ⅳ期)的预测价值。结果:血清5-HT、SP水平,Ⅰ期组、Ⅱ期组、Ⅲ期组、Ⅳ期组逐渐升高,无痛经组、轻度痛经组、中度痛经组、重度痛经组逐渐升高,Spearman相关分析,血清5-HT、SP与EMT患者临床分期、痛经程度均呈正相关(均P<0.05)。血清5-HT、SP预测EMT患者临床分期(Ⅳ期)的曲线下面积(AUC)分别为0.857、0.749,截点值分别为114.13ng/ml、79.79μg/ml,特异度分别为66.9%、57.0%,灵敏度分别为91.4%、91.4%,二者联合预测的AUC为0.904,特异度87.1%,灵敏度为85.1%。结论:EMT患者血清5-HT、SP水平与临床分期和痛经程度正相关,且二者可作为预测EMT患者临床分期(Ⅳ期)的生物标记物。Objective:To investigate the correlation between the serum 5-hydroxytryptamine(5-HT)and substance P(SP)levels of patients with endometriosis(EMT)and their clinical stage of endometriosis and dysmenorrhea degree.Methods:97 patients with EMT were selected in this study from October 2021 to September 2023.These patients were divided into group A1(22 cases with EMT stage Ⅰ),group A2(37 cases with EMT stage Ⅱ),group A3(25 cases with EMT stage Ⅲ)and group A4(13 cases with EMT stage Ⅳ)according to the clinical EMT stages of the patients.According to the degree of the dysmenorrhea of the patients,these patients were divided into group B1(11 cases without dysmenorrhea),group B2(27 cases with mild dysmenorhea),group B3(36 cases with moderate dysmenorrhea)and group B4(23 cases with severe dysmenorrhea).The levels of serum 5-HT and SP were compared among the patients with different clinical EMT stages and among the patients with different dysmenorrhea severity.Spearman correlation analysis was used to investigate the correlation between the levels of serum 5-HT and SP of the patients with EMT and their clinical EMT stage and dysmenorrhea severity.The predictive value of the serum 5-HT and SP levels of the patients with EMT for their clinical EMT stage(EMT stage Ⅳ)was evaluated by receiver operating characteristic(ROC)curve.Results:The levels of the serum 5-HT and SP of the patients in group A1,in group A2,in group A3 and in group A4 had increased gradually,and which of the patients in group Bl,in group B2,in group B3 and in group B4 had increased gradually.Spearman correlation analysis showed that the levels of the serum 5-HT and SP of the patients with EMT were positively correlated with their clinical EMT stage and their dysmenorrhea severity(all P<0.05).The area under the curve(AUC)of the serum 5-HT level and the SP level of the patients for predicting their EMT clinical EMT stage(EMT stage Ⅳ)were 0.857 and 0.749,the cut-off value of which were 114.13ng/ml and 79.79μg/ml,the specificity of which were 66.9%and

关 键 词：子宫内膜异位症 5-羟色胺 P物质 临床分期 痛经程度 相关性 预测 

分 类 号：R71[医药卫生—妇产科学]