PE孕妇血清Omentin-1、PLGF水平与HOMA-IR相关性及其预测不良妊娠结局价值  

Correlation between the levels of the serum Omentin-1 and placental growth factor of pregnant women with preeclampsia and their value of homeostasis model assessment of insulin resistance,and their predictive values for adverse pregnancy outcomes

作　　者：郭畅[1] 郑婷华 王丽丽 张加盟 栾青春 赵东婷 宋志慧[1] GUO Chang;ZHENG Tinghua;WANG Lili;ZHANG Jiameng;LUAN Qingchun;ZHAO Dongting;SONG Zhihui(Tangshan Maternal and Child Health Care Hospital,Tangshan,Hebei Province,063000)

机构地区：[1]河北省唐山市妇幼保健院,063000

出　　处：《中国计划生育学杂志》2025年第3期700-704,共5页Chinese Journal of Family Planning

摘　　要：目的:探究子痫前期(PE)孕妇血清网膜素1(Omentin-1)、胎盘生长因子(PLGF)水平与胰岛素抵抗相关性,及其对不良妊娠结局的预测价值。方法:回顾性收集2021年1月-2022年12月本院就诊的PE孕妇250例临床资料为PE组,同期产前检查年龄、孕前体重匹配、无妊娠合并症及并发症的相同孕周的孕妇250例为对照组。检测孕妇血清Omentin-1、PLGF、空腹血糖(FPG)、空腹胰岛素(FINS)水平,计算胰岛素抵抗指数(HOMA-IR),采用Pearson相关分析PE组Omentin-1、PLGF与胰岛素抵抗相关性。PE组按妊娠结局分为结局不良组与结局良好组,采用logistic回归分析影响PE孕妇妊娠结局的因素,受试者工作特征(ROC)曲线分析Omentin-1、PLGF预测PE孕妇不良妊娠结局效能。结果:PE组血清Omentin-1(215.40±40.12 ng/ml)、PLGF(146.45±21.27 pg/ml)水平低于对照组(357.35±47.86 ng/ml、314.73±39.10 pg/ml),HOMA-IR(2.38±0.40)高于对照组(1.17±0.30),Pearson相关分析,PE孕妇血清Omentin-1、PLGF水平与HOMA-IR均呈负相关(均P<0.05)。PE组不良妊娠结局总发生率高于对照组(P<0.05)。logistic回归分析显示,发病孕周<34周、舒张压≥110 mmHg、Omentin-1降低、PLGF降低均为影响PE孕妇妊娠结局的相关因素(均P<0.05)。ROC显示,血清Omentin-1、PLGF水平预测PE孕妇不良妊娠结局的曲线下面积分别为0.789、0.776,有较好预测价值(均P<0.05)。结论:PE孕妇血清Omentin-1、PLGF水平异常下降,且二者水平与胰岛素抵抗、不良妊娠结局有关,可作为临床评估PE孕妇妊娠结局的有效指标。Objective:To explore the correlation between the levels of serum Omentin-1 and placental growth factor(PLGF)of pregnant women with preeclampsia(PE)and their value of homeostasis model assessment of insulin resistance(HOMA-IR),and to study the predictive values of the levels of serum Omentin-1 and placental growth factor of the women for their adverse pregnancy outcomes.Methods:The clinical data of 250 pregnant women with PE(in study group)treated in the hospital from January 2021 to December 2022 were collected retrospectively.250 pregnant women with the same gestational weeks and without pregnancy complications who matching the age and the pre-pregnancy weight the women in the study group were selected in control group during the same period.The levels of the serum Omentin-1,PLGF,fasting plasma glucose(FPG)and fasting insulin(FINS)of the pregnant women in the two groups were detected.The HOMA-IR value of the women was calculated.Pearson correlation analysis was used to analyze the correlation between the Omentin-1 and PLGF levels of the women in the study group and their insulin resistance.The women in the study group were divided into group A(women with adverse pregnancy outcomes)and group B(women with normal pregnancy outcomes)according to the pregnancy outcomes of the women.Logistic regression analysis was used to analyze the factors affecting the pregnancy outcomes of the pregnant women with PE.Receiver operating characteristic(ROC)curve was used to analyze the efficacy of the Omentin-1 and PLGF levels of the women with PE for predicting their adverse pregnancy outcomes.Results:The levels of the serum Omentin-1(215.40±40.12 ng/ml)and PLGF(146.45±21.27 pg/ml)of the women in the study group were significantly lower than those(357.35±47.86 ng/ml and 314.73±39.10 pg/ml)of the women in the control group.The HOMA-IR value(2.38±0.40)of the women in the study group was significantly higher than that(1.17±0.30)of the women in the control group.Pearson correlation analysis showed that the serum Omentin-1 and PLG

关 键 词：子痫前期 网膜素 胎盘生长因子 胰岛素抵抗 不良妊娠结局 评估 影响因素 

分 类 号：R71[医药卫生—妇产科学]