盐酸拉贝洛尔片联合维生素D治疗HDP对患者血液流变学状态、氧化应激指标的影响  

Influence of labetalol hydrochloride tablets combined with vitamin D for treating pregnant women with hypertensive disorder during pregnancy on their hemorheological status and oxidative stress indicators

作　　者：高佳丽 侯向娟 吴棣 高妍 樊秀梅 GAO Jiali;HOU Xiangjuan;WU Di;GAO Yan;FAN Xiumei(Xingtai Central Hospital,Xingtai,Hebei Province,054000)

机构地区：[1]河北省邢台市中心医院,054000

出　　处：《中国计划生育学杂志》2025年第3期705-709,共5页Chinese Journal of Family Planning

基　　金：邢台市科学技术局重点研发计划自筹项目(2020ZC271)。

摘　　要：目的:观察盐酸拉贝洛尔联合维生素D治疗妊娠期高血压疾病(HDP)对患者血液流变学状态、氧化应激指标的影响。方法:回顾性分析2022年8月-2023年12月本院收治的HDP患者108例临床资料,根据治疗方式不同分组,常规治疗基础上予以盐酸拉贝洛尔片联合维生素D治疗56例纳入联合组,常规治疗基础予以盐酸拉贝洛尔片治疗52例纳入对照组。观察两组治疗前后血压[收缩压(SBP)、舒张压(DBP)],血液流变学状态[血浆黏度(PV)、高切全血黏度、低切全血黏度、红细胞压积(HCT)],氧化应激指标[丙二醛、谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)],母婴结局。结果:治疗15天后,两组SBP、DBP、PV、高切全血黏度、低切全血黏度、HCT、丙二醛水平均下降,两组GSH-Px、SOD水平均上升,且联合组上述指标变化幅度均大于对照组(均P<0.05);两组分娩方式无差异,新生儿窒息发生率无差异(P>0.05)。结论:盐酸拉贝洛尔片联合维生素D治疗HDP可有效降低患者血压水平,改善血液流变学状态,减少机体氧化应激水平,且未对母婴结局产生不良影响。Objective:To observe the influence of labetalol hydrochloride tablets combined with vitamin D for treating pregnant women with hypertensive disorder during pregnancy(HDP)on their hemorheological status and oxidative stress indicators.Methods:The clinical data of 108 pregnant women with HDP were analyzed retrospectively.According to the different treatment methods,56 women who were treated with labetalol hydrochloride tablets combined with vitamin D and the conventional treatment were included in study group,and 52 patients who received labetalol hydrochloride tablets combined with the conventional treatment were included in control group.The values of blood pressure,such as systolic blood pressure(SBP)and diastolic blood pressure(DBP),the values of the hemorheological status indexes,such as plasma viscosity(PV),high shear whole blood viscosity,low shear whole blood viscosity and hematocrit(HCT),the levels of the oxidative stress indexes,such as malondialdehyde,glutathione peroxidase(GSH-Px)and superoxide dismutase(SOD),of the women,and the maternal-infant outcomes in the two groups before and after treatment were observed.Results:After 15 days of treatment,the values of SBP,DBP,PV,high shear whole blood viscosity and low shear whole blood viscosity,and the levels of HCT and malondialdehyde of the women in the two groups had decreased significantly,and the levels of GSH-Px and SOD of the women in the two groups had increased significantly,and the changes of which of the women in the study group were significantly greater than those of the women in the control group(all P<o.05).There were no significant differences in the delivery mode and the incidence of the neonatal asphyxia of the women between the two groups(P>0.05).Conclusion:The application of labetalol hydrochloride tablets combined with vitamin D for treating the pregnant women with HDP can effectively reduce their blood pressure,improve their hemorheological status and reduce their oxidative stress level,and which has no adverse influence on the maternal-

关 键 词：妊娠期高血压疾病 盐酸拉贝洛尔 维生素D 氧化应激指标 血液流变学指标 母婴结局 

分 类 号：R71[医药卫生—妇产科学]