GDM孕妇血清HIF-1α、HO-1、Hcy水平与发生胎儿宫内窘迫关系  

Correlation between the levels of the serum hypoxia inducible factor-1α,heme oxygenase-1 and homocysteine of pregnant women with gestational diabetes mellitus and their fetal intrauterine distress occurrence

作　　者：杨玲珠 熊英 郑小燕 卢晓燕 YANG Lingzhu;XIONG Ying;ZHENG Xiaoyan;LU Xiaoyan(Linhai Maternity and Child Health Care Hospital,Linhai,Zhejiang Province,317000;Taizhou Hospital,Zhejiang Province)

机构地区：[1]浙江省临海市妇幼保健院,317000 [2]浙江省台州医院

出　　处：《中国计划生育学杂志》2025年第3期718-722,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨妊娠期糖尿病(GDM)患者血清缺氧诱导因子-1α(HIF-1α)、血红素加氧酶-1(HO-1)、同型半胱氨酸(Hcy)水平及与胎儿宫内窘迫(FIUD)关系。方法:选取本院2023年1月-2024年1月收治的GDM患者268例临床资料,治疗前酶联免疫吸附法检测血清HIF-1α、HO-1、Hcy水平;随访至分娩结束,根据GDM患者FIUD发生情况分为FIUD组、非FIUD组,比较两组临床资料及血清HIF-1α、HO-1、Hcy水平;Pearson分析患者血清HIF-1α、HO-1、Hcy水平与FIUD的相关性,多因素logistic回归分析FIUD发生影响因素。结果:纳入的GDM患者FIUD发生率为33.6%(90/268);FIUD组产前体质指数(BMI)、合并妊娠期高血压综合征(HDP)、过期妊娠占比,以及血清HIF-1α(117.41±20.45 pg/L)、HO-1(85.54±9.41 ng/L)、Hcy水平(14.61±2.12μmol/L)、胎儿脐动脉S/D值均高于非FIUD组(102.42±19.42 pg/L、73.82±8.88 ng/L、11.16±2.09μmol/L),妊娠期BMI增幅大于非FIUD组(均P<0.05);Pearson分析显示,血清HIF-1α、HO-1、Hcy水平与GDM患者发生FIUD均呈正相关(P<0.05);多因素logistic回归分析,妊娠期BMI增幅加大、HDP、HIF-1α升高、HO-1升高、Hcy升高、胎儿脐动脉S/D值升高、过期妊娠均为GDM患者FIUD发生的影响因素(均P<0.05)。结论:GDM患者血清HIF-1α、HO-1、Hcy水平异常升高且与FIUD发生存在相关性,是FIUD发生的影响因素。Objective:To explore the correlation between the levels of the serum hypoxia inducible factor-1α(HIF-1α),heme oxygenase-1(HO-1)and homocysteine(Hcy)of pregnant women with gestational diabetes mellitus(GDM)and their fetal intrauterine distress(FIUD)occurrence,Methods:The clinical data of 268 pregnant women with GDM who admitted to the hospital from January 2023 to January 2024 were selected in this study.The levels of serum HIF-1α,HO-1 and Hcy of these women before treatment were detected by enzyme-linked immunosorbent assay(ELISA).These women were followed up to the end of delivery.The incidence of FIUD of the women with GDM was counted.These women were divided into group A(women with FIUD)and group B(women without FIUD)according to the presence or absence of FIUD occurrence.The clinical data and the serum HIF-1α,HO-1 and Hcy levels of the women were compared between the two groups.The correlation between the serum HIF-1α,HO-1 and Hcy levels of the women with GDM and their FIUD occurrence was analyzed by Pearson analysis.The influencing factors of FIUD occurrence of the women with GDM was analyzed by multivariate logistic regression.Results:The incidence of FIUD occurrence of the women with GDM was 33.6%(90/268).The prenatal body mass index(BMI),the proportions of the complicated with hypertensive disorders of pregnancy(HDP)and the post-term pregnancy,and the S/D value of the fetal umbilical artery of the women in group A were significantly higher than those of the women in group B.The levels of serum HIF-1α(117.41±20.45 pg/L),HO-1(85.54±9.41 ng/L)and Hcy(14.61±2.12μmol/L)of the women in group A were significantly higher than those(102.42±19.42 pg/L,73.82±8.88 ng/L and 11.16±2.09μmol/L)of the women in group B.The increased BMI of the women in group A was significantly more than that of the women in group B(all P<0.05).Pearson analysis showed that the levels of serum HIF-1α,HO-1 and Hcy of the women with GDM were positively correlated with their FIUD occurrence(P<0.05).Multivariate logistic regressi

关 键 词：妊娠期糖尿病 胎儿宫内窘迫 缺氧诱导因子-1α 血红素加氧酶-1 同型半胱氨酸 相关性 影响因素 

分 类 号：R71[医药卫生—妇产科学]