瑞马唑仑和丙泊酚用于全麻手术患者术后谵妄发生率的比较:一项Meta分析  

Comparison of Postoperative Delirium Incidence between Remifentanil and Propofol in Patients Undergoing General Anesthesia Surgery:a Metaanalysis

作　　者：李香洁 谌天奇 李益英 刘真 张永明 郭婧 LI Xiangjie;SHEN Tianqi;LI Yiying;LIU Zhen;ZHANG Yongming;GUO Jing(Department of Anesthesiology,the 984th Hospital of the Joint Logistics Support Force,Beijing 100094,China)

机构地区：[1]联勤保障部队第九八四医院麻醉科,北京100094

出　　处：《药学与临床研究》2025年第1期31-34,共4页Pharmaceutical and Clinical Research

摘　　要：目的:比较瑞马唑仑与丙泊酚用于全麻手术患者术后谵妄的发生率。方法:计算机检索PubMed、Cochrane图书馆、Embase数据库、中国知网、万方数据知识服务平台、中国生物医学文献服务系统(SinoMed)和维普中文期刊全文数据库,检索日期为建库至2024年1月,纳入实验组为瑞马唑仑、对照组为丙泊酚,应用于全麻手术患者术后谵妄发生率的随机对照试验。从符合纳入及排除标准的文献中提取数据,用R4.3.2统计学软件进行分析。结果与结论:共纳入6篇随机对照试验,共计849例患者。Meta分析结果显示,丙泊酚与瑞马唑仑用于全麻手术患者术后谵妄的发生率差异无统计学意义(OR=0.843,95%CI0.400~1.776)。Objective:To compare the incidence of postoperative delirium in patients undergoing gen-eral anesthesia surgery with remimazolam or propofol.Methods:Computer searches were conducted on PubMed,Cochrane Library,Embase,CNKI,Wanfang Data,SinoMed and VIP Chinese Journal Full-text Database from their inception to January 2024.Randomized controlled trials(RCTs)were included,where the experimental group received remimazolam and the control group received propofol,focusing on the inci-dence of postoperative delirium in patients undergoing general anesthesia.Data were extracted from studies meeting the inclusion and exclusion criteria,and statistical analysis was performed using the R 4.3.2 soft-ware.Results&Conclusion:A total of 6 RCTs involving 849 patients were included.Meta-analysis results showed no statistically significant difference in the incidence of postoperative delirium between pro-pofol and remimazolam in patients undergoing general anesthesia(OR=0.843,95%CI 0.400-1.776).

关 键 词：瑞马唑仑 丙泊酚 谵妄 META分析 

分 类 号：R971.2[医药卫生—药品]