1例耐碳青霉烯-替加环素肺炎克雷伯菌多系统感染婴儿的治疗实践  

Treatment Practice of a Case of Carbapenem Tigecycline Resistant Klebsi⁃ella Pneumoniae Multisystem Infection in an Infant

作　　者：洪文英[1] 黄亮[2] HONG Wenying;HUANG Liang(Department of Pharmacy,Wenjiang District People’s Hospital,Chengdu 611130,China;Department of Pharmacy,West China Second Hospital,Sichuan University,Chengdu 610011,China)

机构地区：[1]成都市温江区人民医院药学部,成都611130 [2]四川大学华西第二医院药学部,成都610011

出　　处：《药学与临床研究》2025年第1期75-77,共3页Pharmaceutical and Clinical Research

摘　　要：1例耐碳青霉烯-替加环素肺炎克雷伯菌致多系统感染的4月龄婴儿,最初使用多种抗菌药物(美罗培南、万古霉素、替加环素)联合治疗效果不佳,临床药师依据其病理生理特点、辅助检查结果、药物的药代动力学/药效学特点,给予头孢他啶/阿维巴坦联合多黏菌素B静滴抗感染,并进行治疗药物监测,最终患儿治愈出院,治疗期间未发生药物不良反应。A 4-month-old infant with multiple system infections caused by carbapenem tigecycline resistant Klebsiella pneumoniae was initially treated with a combination of multiple antibiotics(meropenem,vancomycin,tigecycline),but the effect was not satisfactory.Based on its pathological and physiological characteristics,auxiliary examination results,and pharmacokinetic/pharmacodynamic characteristics of drugs,the clinical pharmacists suggested ceftazidime/avibactam combined with polymyxin B intravenous infusion for anti-infection treatment,and monitored the therapeutic drugs.The child was eventually cured and discharged without any adverse drug reactions during the treatment period.

关 键 词：婴儿 耐碳青霉烯-替加环素肺炎克雷伯菌 头孢他啶/阿维巴坦 抗感染治疗 

分 类 号：R969.3[医药卫生—药理学]