脓毒症相关凝血病的舌下微循环特点及炎症-凝血-微循环指标与短期预后的相关性研究  

Study on the characteristics of sublingual microcirculation in sepsis-associated coagulopathy and the correlation between inflammation-coagulation microcirculation indicators and short-term prognosis

作　　者：姜紫洋 周亚雄[1] 曹钰[1] JIANG Ziyang;ZHOU Yaxiong;CAO Yu(Department of Emergency,West China Hospital,Sichuan University,Chengdu,610041,China)

机构地区：[1]四川大学华西医院急诊科,成都610041

出　　处：《临床急诊杂志》2025年第1期24-30,共7页Journal of Clinical Emergency

基　　金：四川省科技厅基金(No:2023NSFSC1472)。

摘　　要：目的:探讨脓毒症相关凝血病患者舌下微循环特征及凝血、炎症及舌下微循环指标对其短期预后的影响。方法:采用回顾性队列研究,纳入2023年12月1日—2024年6月30日在四川大学华西医院急诊科就诊且符合脓毒症相关凝血病诊断的患者,收集患者入院后48 h内酸碱度、血乳酸水平、平均动脉压、白细胞计数、血小板计数、降钙素原水平、活化部分凝血活酶时间(activated partial thromboplastin time,APTT)、血浆凝血酶原时间、国际正常化比值、纤维蛋白原、D-二聚体及舌下微循环指标。并根据总小血管密度(total vessels density small,TVDs)、灌注小血管密度(perfused vessels density small,PVDs)、灌注血管比例(proportion of perfused vessels,PPV)、微血管流动指数、异质性指数,将总体分为:淤滞型、稀释型、变异型和高动力型舌下微循环障碍,随访患者28 d生存情况。采用logistic回归模型分析影响脓毒症相关凝血病患者28 d病死率的炎症-凝血-微循环危险因素。结果:共纳入101例脓毒症相关凝血病患者,其中淤滞型8例(7.9%),稀释型15例(14.9%),变异型31例(30.7%),高动力型47例(46.5%)。单因素分析发现,各型间的TVDs、PVDs、PPV、28 d生存率差异有统计学意义。其中,淤滞型患者的PPV及28 d生存率均显著低于其他组,同时稀释型患者的总(灌注)血管密度显著低于其他组,差异有统计学意义(P<0.05)。二元logistic回归分析显示,APTT(OR=0.136,95%CI:1.045~1.257,P=0.004)、D-二聚体(OR=0.083,95%CI:1.023~1.154,P=0.007)、降钙素原(OR=0.089,95%CI:1.037~1.153,P=0.001)、灌注血管密度(OR=-5.54,95%CI:0.01~0.73,P=0.038)为影响脓毒症28 d病死率的独立危险因素。结论:脓毒症相关凝血病患者呈现特异性微循环障碍,其中淤滞型占比较高且预后差,炎症、凝血及微循环指标与短期预后独立相关。Objective:To explore the characteristics of sublingual microcirculation and the impact of coagulation,inflammation and sublingual microcirculation indicators on short-term prognosis in patients with sepsis-associated coagulopathy.Methods:A retrospective cohort study was conducted,including patients diagnosed with sepsis-associated coagulopathy who visited the emergency department of West China Hospital,Sichuan University,between December 1,2023and June 30,2024.Data collected within 48hours of admission included pH,blood lactate levels,mean arterial pressure,white blood cell count,platelet count,procalcitonin levels,activated partial thromboplastin time(APTT),prothrombin time,international normalized ratio,fibrinogen,D-dimer and sublingual microcirculation parameters.According to the total small vessel density(TVDs),perfused small vessel density(PVDs),perfused vessel ratio(PPV),microvascular flow index(MFI)and heterogeneity index,patients were divided into four types of sublingual microcirculatory disorders:stagnation type,dilution type,variation type and hyperdynamic type.The 28-day survival status was followed up.Logistic regression models were used to analyze the inflammatory-coagulation-microcirculation risk factors affecting 28-day mortality in patients with sepsis-associ ated coagulopathy.Results:A total of 10l patients with sepsis-associated coagulopathy were included,among which 8 patients(7.9%)were classified as stagnation type,15(14.9%)as dilution type,31(30.7%)as variation type and 47(46.5%)as hyperdynamic type.Univariate analysis revealed statistically significant differences in TVDs,PVDs,PPV and 28-day survival rates among the groups.Specifically,the perfused vessel ratio and 28-day survival rate in the stagnation type were significantly lower than those in the other groups,while the total/perfused vessel density in the dilution type was significantly lower than in the other groups,the difference was statistically significant(P<0.05).Binary logistic regression analysis showed that APTT(OR=0.136,95%CI:

关 键 词：脓毒症 凝血病 凝血功能异常 微循环障碍 短期预后 

分 类 号：R459.7[医药卫生—急诊医学]