Recent Advances in the Development of Indolizine Scaffolds:Synthetic Methodology and Mechanistic Insights  

作　　者：Jiuzhong Huang Chunsheng Li Xiaoning Li Guangyu Li Ziyi Yang Yinke Yu Yanping Xie Hao Huang Fuchao Yu Zhihua He 

机构地区：[1]First Affiliated Hospital,Gannan Medical University,Ganzhou,Jiangxi,341000 China [2]Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine,School of Pharmacy,Gannan Medical University,Ganzhou,Jiangxi,341000 China [3]School of Chemistry and Chemical Engineering,Zhaoqing University,Zhaoqing,Guangdong,526060 China [4]Faculty of Life Science and Technology,Kunming University of Science and Technology,Kunming,Yunnan,650500 China

出　　处：《Chinese Journal of Chemistry》2025年第3期315-348,共34页中国化学(英文版)

基　　金：supported by the National Natural Science Foundation of China(22361003);Jiangxi Provincial Science Foundation for Distinguished Young Scholars(20212ACB216002);the Youth JinggangScholars Program in JiangxiProvince(QNJG2019089);the Jiangxi Provincial Natural Science Foundation(20224BAB216005,20242BAB25591);the Yunnan Revitalization Talent Support Program“Young Talent”Project and the Research Foundation of Zhaoqing University(ZD202413).

摘　　要：Indolizine is a nitrogen-containing heterocycle with strong aromaticity,possessing a delocalized 10π-electron system.Based on the indolizine scaffolds,numerous molecules with biological activity and organic functional materials have been synthesized.Since 2016,over 110 papers have been published on the synthesis of indolizine scaffolds,but the reviews on synthesizing indolizine scaffolds have been incomplete and not up-to-date.Herein,from the perspective of the structure of indolizine with the combination of pyrrole and pyridine ring,we focus on the construction of indolizine scaffolds through the diversity of starting substrates,including pyridine derivatives(N1-substituted pyridinium salt derivatives,C2-substituted pyridine derivatives,N1-and C2-free substituted pyridine derivatives),pyrrole derivatives and unoriginal ring substrates.Furthermore,the corresponding reaction mechanisms of synthetic methodologies are also elaborated.Therefore,this review not only paves the way for indolizine synthesis but also provides insight into exploring new reaction modes for constructing nitrogen-containing heterocycles.

关 键 词：Indolizine scaffolds Synthetic methodology Mechanistic insights Pyridine derivatives Pyrrole derivatives Unoriginal ring substrates 

分 类 号：TQ2[化学工程—有机化工]