糖尿病周围神经病变线粒体机制研究进展  

Advances in mitochondrial mechanisms of diabetic peripheral neuropathy

作　　者：曹迪 肖礼祖[1] 樊碧发[2] 熊东林[1] 彭莉萍[3] 孙武平 CAO Di;XIAO Li-zu;FAN Bi-fa;XIONG Dong-lin;PENG Li-ping;SUN Wu-ping(Department of Pain Medicine,Shenzhen Nanshan People's Hospital,Shenzhen Key Laboratory of Pain Science,Shenzhen 518052,China;Department of Pain Medicine,China-Japan Friendship Hospital,Beijing 100029,China;Department of Traditional Chinese Medicine,Shenzhen Nanshan People's Hospital,Shenzhen 518052,China)

机构地区：[1]深圳市南山区人民医院疼痛科深圳市疼痛学重点实验室,深圳518052 [2]中日友好医院疼痛科,北京100029 [3]深圳市南山区人民医院中医科,深圳518052

出　　处：《中国疼痛医学杂志》2025年第3期164-171,共8页Chinese Journal of Pain Medicine

基　　金：南山区卫生健康系统科技重大项目(NSZD2024007、NSZD2023003);广东省中医药局科技项目(20232150);深圳市南山区科技计划项目(NS2022039);深圳市南山区人民医院院级课题(YN2022038);深圳市医疗卫生三名工程引进“中日友好医院樊碧发教授疼痛医学团队”项目(SZSM202103018)。

摘　　要：糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)是糖尿病最常见的慢性并发症,其中痛性糖尿病周围神经病变(painful diabetic peripheral neuropathy,PDPN)导致的慢性疼痛严重影响病人的生活质量。线粒体作为神经元的主要能量来源,对维持神经元的结构和功能至关重要。大量的研究表明,线粒体与DPN的发病密切相关,其病理机制涉及氧化应激、钙稳态失衡以及能量生成障碍等方面,诱发神经元凋亡,从而引起神经损伤,最终导致神经病理性疼痛。目前许多药物通过调控线粒体功能,发挥镇痛作用,表明调控线粒体功能障碍可能是有效治疗神经病理性疼痛的策略之一。本文将从线粒体功能障碍出发,对其在DPN中的发病机制进行综述,为预防和治疗DPN提供理论参考。Diabetic peripheral neuropathy(DPN)is the most common chronic complication of diabetes,in which chronic pain caused by painful diabetic peripheral neuropathy(PDPN)seriously affects patients'quality of life.As the main energy source of neurons,mitochondria are crucial for maintaining the structure and function of neurons.A large number of studies have shown that mitochondria is closely related to the pathogenesis of PDPN,and its pathological mechanism involves oxidative stress,calcium homeostasis imbalance and energy generation disturbance,which induces neuronal apoptosis,thereby causing nerve damage and ultimately lead to neuropathic pain.At present,many drugs exert analgesic effects by regulating mitochondrial function,suggesting that regulating mitochondrial dysfunction may be the effective strategies to treat neuropathic pain.This article will review the pathogenesis of mitochondrial dysfunction in DPN,hoping to provide theoretical reference for the prevention and treatment of DPN.

关 键 词：糖尿病 糖尿病周围神经病变 线粒体 氧化应激 神经损伤 疼痛 

分 类 号：R587.2[医药卫生—内分泌]