Thirteen serum biochemical indexes and five whole blood coagulation indices in a point-of-care testing analyzer:ideal protocol for evaluating pulmonary and critical care medicine  

作　　者：Mingtao LIU Li LIU Jiaxi CHEN Zhifeng HUANG Huiqing ZHU Shengxuan LIN Weitian QI Zhangkai J.CHENG Ning LI Baoqing SUN 

机构地区：[1]Department of Clinical Laboratory,Guangzhou Institute of Respiratory Health,State Key Laboratory of Respiratory Disease,National Center for Respiratory Medicine,National Clinical Research Center for Respiratory Disease,Guangzhou Laboratory,The First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510140,China [2]KingMed School of Laboratory Medicine,Guangzhou Medical University,Guangzhou 511495,China [3]College of Medical Technology,Guangdong Medical University,Dongguan 523121,China [4]Second Clinical Medical School,Southern Medical University,Guangzhou 510515,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2025年第2期158-171,共14页浙江大学学报(英文版)B辑(生物医学与生物技术)

基　　金：supported by the National Natural Science Foundation of China(No.82302607);the Guangdong Basic and Applied Basic Research Foundation(Nos.2022A1515110555 and 2023A1515010932);the State Key Laboratory of Respiratory Disease(No.SKLRD-Z-202410);the Precision Medicine Joint Foundation of Basic and Applied Basic Research Foundation of Guangdong Province(No.2021B1515230008);the Independent Project of Guangdong-Hong Kong-Macao Joint Laboratory for Respiratory Infectious Diseases(No.GHMJLRID-Z-202102);the Guangdong Zhong Nanshan Medical Foundation(No.ZNSXS-20220015).

摘　　要：The accurate and timely detection of biochemical coagulation indicators is pivotal in pulmonary and critical care medicine.Despite their reliability,traditional laboratories often lag in terms of rapid diagnosis.Point-of-care testing(POCT)has emerged as a promising alternative,which is awaiting rigorous validation.We assessed 226 samples from patients at the First Affiliated Hospital of Guangzhou Medical University using a Beckman Coulter AU5821 and a PUSHKANG POCT Biochemistry Analyzer MS100.Furthermore,350 samples were evaluated with a Stago coagulation analyzer STAR MAX and a PUSHKANG POCT Coagulation Analyzer MC100.Metrics included thirteen biochemical indexes,such as albumin,and five coagulation indices,such as prothrombin time.Comparisons were drawn against the PUSHKANG POCT analyzer.Bland-Altman plots(MS100:0.8206-0.9995;MC100:0.8318-0.9911)evinced significant consistency between methodologies.Spearman correlation pinpointed a potent linear association between conventional devices and the PUSHKANG POCT analyzer,further underscored by a robust correlation coefficient(MS100:0.713-0.949;MC100:0.593-0.950).The PUSHKANG POCT was validated as a dependable tool for serum and whole blood biochemical and coagulation diagnostics.This emphasizes its prospective clinical efficacy,offering clinicians a swift diagnostic tool and heralding a new era of enhanced patient care outcomes.

关 键 词：Thirteen serum biochemical indexes Five whole blood coagulation indices Point-of-care testing(POCT) Pulmonary and critical care medicine Diagnostic protocol 

分 类 号：R44[医药卫生—诊断学]