Association between post-COVID-19 sleep disturbance and neurocognitive function:a comparative study based on propensity score matching  

作　　者：Shixu DU Leqin FANG Yuanhui LI Shuai LIU Xue LUO Shufei ZENG Shuqiong ZHENG Hangyi YANG Yan XU Dai LI Bin ZHANG 

机构地区：[1]Department of Psychiatry,Sleep Medicine Center,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China [2]Key Laboratory of Mental Health of the Ministry of Education,Guangzhou 510515,China [3]Adai Technology(Beijing)Company Limited,Beijing 100083,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2025年第2期172-184,共13页浙江大学学报(英文版)B辑(生物医学与生物技术)

基　　金：supported by the National Key R&D Pro-gram of China(No.2021YFC2501500);the National Natural Science Foundation of China(Nos.82271525 and 82071488);the Nanfang Hospital Clinical Research Project of Southern Medical University(No.2021CR009),China。

摘　　要：Despite that sleep disturbance and poor neurocognitive performance are common complaints among coronavirus disease 2019(COVID-19)survivors,few studies have focused on the effect of post-COVID-19 sleep disturbance(PCSD)on cognitive function.This study aimed to identify the impact of PCSD on neurocognitive function and explore the associated risk factors for the worsening of this condition.This cross-sectional study was conducted via the web-based assessment in Chinese mainland.Neurocognitive function was evaluated by the modified online Integrated Cognitive Assessment(ICA)and the Number Ordering Test(NOT).Propensity score matching(PSM)was utilized to match the confounding factors between individuals with and without PCSD.Univariate analyses were performed to evaluate the effect of PCSD on neurocognitive function.The risk factors associated with worsened neurocognitive performance in PCSD individuals were explored using binary logistic regression.A total of 8692 individuals with COVID-19 diagnosis were selected for this study.Nearly half(48.80%)of the COVID-19 survivors reported sleep disturbance.After matching by PSM,a total of 3977 pairs(7954 individuals in total)were obtained.Univariate analyses revealed that PCSD was related to worse ICA and NOT performance(P<0.05).Underlying disease,upper respiratory infection,loss of smell or taste,severe pneumonia,and self-reported cognitive complaints were associated with worsened neurocognitive performance among PCSD individuals(P<0.05).Furthermore,aging,ethnicity(minority),and lower education level were found to be independent risk factors for worsened neurocognitive performance in PCSD individuals(P<0.05).PCSD was related to impaired neurocognitive performance.Therefore,appropriate prevention and intervention measures should be taken to minimize or prevent PCSD and eliminate its potential adverse effect on neurocognitive function.

关 键 词：Coronavirus disease 2019(COVID-19) Post-COVID-19 Sleep disturbance Neurocognitive function Digital assessment 

分 类 号：R71[医药卫生—妇产科学]