湿热论治重症肺炎患者多重耐药菌感染的临床观察  

Clinical observation on the treatment of severe pneumonia patients with multi-drug resistant bacterial infections based on the dampness-heat theory in TCM

作　　者：罗卫东 张军[1] 舒婷婷 李汉永 饶明月 唐瑜 周敏 LUO Wei-dong;ZHANG Jun;SHU Ting-ting;LI Han-yong;RAO Ming-yue;TANG Yu;ZHOU Min(Wuhan Hospital of Traditional Chinese Medicine,Wuhan 430050,China)

机构地区：[1]武汉市中医医院,湖北武汉430050

出　　处：《时珍国医国药》2025年第3期493-496,共4页Lishizhen Medicine and Materia Medica Research

基　　金：湖北省自然科学基金(2022CFB373);武汉市科技局知识创新专项曙光计划项目(2022020801020586)。

摘　　要：目的观察中药甘露消毒丹汤剂外擦联合针刺治疗重症肺炎患者多重耐药菌感染的疗效以及对C反应蛋白(CRP)、降钙素原(PCT)、白介素-6(IL-6)水平的影响。方法选择多重耐药菌感染重症肺炎患者82例,按照随机数字表法分为两组,每组41例,对照组给予常规治疗方案,用药组在对照组基础上给予外擦甘露消毒丹联合针刺治疗。治疗前、后测量两组患者CRP、PCT、IL-6以及中医证候积分的改变,比较两组患者临床疗效、不良反应发生率等。结果治疗后,两组CRP、PCT、IL-6均显著下降,且用药组明显低于对照组,差异具有统计学意义(P<0.05)。治疗后用药组的中医症候积分显著低于对照组(P<0.05)。用药组患者总有效率显著高于对照组(P<0.05)。两组治疗期间均未发生明显不良反应。结论外擦甘露消毒丹联合针刺治疗重症肺炎多重耐药菌感染的患者,可以明显降低炎症指标,改善临床症状,提高临床治疗效果。Objective To evaluate the clinical efficacy of Ganlu Xiaodu Pill Decoction(GXPD)application combined with acupuncture in treating severe pneumonia(SP)caused by multi-drug resistant bacteria(MDRB)and its impact on C-reactive protein(CRP),procalcitonin(PCT),and interleukin-6(IL-6)levels.Methods A total of 82 patients with SP were randomly divided into the control group and the treatment group,with 41 cases in each.The control group received conventional treatment,while the treatment group was additionally treated with GXPD application and acupuncture.CRP,PCT,and IL-6 levels,as well as traditional Chinese medicine(TCM)syndrome scores,were measured before and after treatment.Clinical efficacy and adverse reaction rates were compared between the two groups.Results After treatment,the levels of CRP,PCT and IL-6 in both groups were significantly decreased,and the treatment group was significantly lower than the control group(P<0.05).TCM syndrome scores in the treatment group were also significantly lower than those in the control group after treatment(P<0.05).The total effective rate of patients in the treatment group was significantly higher than that in the control group(P<0.05).No significant adverse reactions were observed in either group during the treatment period.Conclusion The combination of GXPD application and acupuncture is effective in treating SP with MDRB by significantly reducing inflammatory markers,alleviating clinical symptoms,and enhancing the overall therapeutic efficacy.

关 键 词：甘露消毒丹 针刺 多重耐药菌感染 重症肺炎 

分 类 号：R259[医药卫生—中西医结合]