肝功能不全体检人群伴血脂异常患者临床病理特点和实验室检查分析  

Analysis of clinicopathological features and laboratory examination of patients with liver dysfunction and dyslipidemia

作　　者：蒋骏 纪艳[1] 马庆华 JIANG Jun;JI Yan;MA Qinghua(School of Public Health and Health Management,Anhui Medical College,Hefei 230601,China;The Third People's Hospital of Xiangcheng District,Suzhou)

机构地区：[1]安徽医学高等专科学校公共卫生与健康管理学院,安徽合肥230601 [2]苏州市相城区第三人民医院

出　　处：《包头医学院学报》2025年第3期13-17,共5页Journal of Baotou Medical College

基　　金：安徽省教育厅自然科学研究重点项目(KJ2020A0855);安徽省教育厅自然科学研究重点项目(KJ2018A0805)。

摘　　要：目的:分析肝功能不全体检人群伴血脂异常患者临床病理特点和实验室检查特征。方法:回顾性分析2019年5月-2022年3月医院收治的135例肝功能不全体检人群的临床资料,根据是否伴有血脂异常分为血脂异常组(n=65)与非血脂异常组(n=70)。所有患者均接受B超检查,对比两组临床资料、临床病理特点、肝功能指标、血脂代谢指标及炎症指标。结果:两组性别、年龄比较差异无统计学意义(P>0.05),血脂异常组肝腹痛占比、腹水占比及总并发症发生率高于非血脂异常组(P<0.05)。血脂异常组肝包膜增厚、回声增强、肝密度降低、肝缘毛糙例数占比高于非血脂异常组(P<0.05)。血脂异常组总胆红素(TBIL)、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)水平高于非血脂异常组(P<0.05)。血脂异常组高密度脂蛋白胆固醇(HDL-C)水平低于非血脂异常组(P<0.05),三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平高于非血脂异常组(P<0.05)。血脂异常组血清C反应蛋白(CRP)、白细胞介素-6(IL-6)水平高于非血脂异常组(P<0.05)。结论:肝功能不全体检人群伴血脂异常患者的临床病理特点主要表现为肝脏功能障碍、血脂代谢紊乱、肝腹水、腹痛、并发症发生率高,肝密度降低、回声增强、肝缘毛糙等表现,且患者炎症反应加重。Objective:To analyze the clinicopathological features and laboratory characteristics of patients with dyslipidemia and liver dysfunction.Methods:The clinical data of 135 patients with liver dysfunction who underwent physical examination in the hospital from May 2019 to March 2022 were retrospectively analyzed.And they were divided into dyslipidemia group(n=60)and non-dyslipidemia group(n=75)according to whether accompanied by dyslipidemia.All patients underwent B-ultrasound examination,and the clinical data,clinicopathological characteristics,liver function indexes,lipid metabolism indexes and inflammatory indexes of were compared between the two groups.R esults:There was no significant difference in gender and age between the two groups(P>0.05).The proportion of liver and abdominal pain,the proportion of ascites and the incidence of total complications in the dyslipidemia group were higher than those in non-dyslipidemia group(P<0.05).The proportion of liver capsule thickening,echo enhancement,liver density decrease and liver margin roughness in dyslipidemia group was higher than that in non-dyslipidemia group(P<0.05).The levels of total bilirubin(TBIL),aspartate aminotransferase(AST)and alanine aminotransferase(ALT)in dyslipidemia group were higher than those in non-dyslipidemia group(P<0.05).The level of high density lipoprotein cholesterol(HDL-C)in dyslipidemia group was lower than that in non-dyslipidemia group(P<0.05),and the levels of triglyceride(TG)and low density lipoprotein cholesterol(LDL-C)in dyslipidemia group were higher than those in non-dyslipidemia group(P<0.05).The levels of serum C-reactive protein(CRP)and interleukin-6(IL-6)in dyslipidemia group were higher than those in non-dyslipidemia group(P<0.05).Conclusion:The clinicopathological features of patients with liver dysfunction and dyslipidemia are mainly characterized by liver dysfunction,dyslipidemia,liver ascites,abdominal pain,high incidence of complications,decreased liver density,enhanced echo,rough liver margin,and increased inflammato

关 键 词：肝功能不全 体检人群 血脂异常 临床病理特点 实验室检查 

分 类 号：R54[医药卫生—心血管疾病]